ArticleJournal of translational medicine2026
Variance-aware penalized panel models for temporal risk detection from wearable sensor data.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWearable devices generate continuous, high-resolution physiological data that offer opportunities for real-time assessment of stress, arousal, and early physiological deterioration, but existing pipelines often treat variability as nuisance noise or rely on labeled classifiers. We present a computational approach for subject-adaptive temporal risk detection that explicitly separates conditional mean and variance dynamics in high-dimensional multisubject sensor data.
resultsThe proposed penalized panel ARX-GARCHX model integrates subject-specific baselines, shared autoregressive dynamics, sparse multimodal covariate effects, and covariate-dependent volatility. It produces an exceedance-based risk score that estimates the conditional probability of crossing an individualized physiological threshold. Simulation experiments across stable, seasonal, transient-regime, and sustained-regime settings showed that modeling covariate-driven variance improves recovery of threshold-exceedance risk when volatility is structured. In the Wearable Stress and Affect Detection (WESAD) demonstration, the score provided an interpretable, label-free temporal summary that separated stress-associated windows more clearly than raw heart-rate summaries and remained lightweight for streaming use.
conclusionVariance-aware penalized panel modeling provides a reproducible methodology for converting noisy wearable streams into subject-adaptive risk-state scores. It is intended for translational feature extraction, with prospective validation required before clinical decision support.
trial registrationNot applicable. This study is a methodological article that uses publicly available secondary data and does not constitute a clinical trial.
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