SynthesisBMC oral health2026
Umbrella review of photobiomodulation/low-level laser therapy and vitamin D in orthodontics: effects on tooth movement, pain, root resorption, and bone biomarkers.
Synthesis in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo synthesize evidence from systematic reviews and meta-analyses on low-level laser therapy/Photobiomodulation (LLLT/PBM) and vitamin D as non-invasive adjuncts for accelerating orthodontic tooth movement (OTM) and mitigating associated side effects.
methodsPubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases were searched from inception to November 18, 2025. SRMAs primarily comprising human RCTs evaluating LLLT/PBM or vitamin D in orthodontics were included; in some mixed-design reviews, clearly separable human orthodontic data from a small number of CCTs were retained narratively. (one pre-registered exception with 4 RCTs for vitamin D to ensure completeness). Randomized controlled trials were prioritized; some retained reviews also included a small number of controlled clinical trials when relevant human orthodontic data were clearly separable. Quality was assessed using AMSTAR-2, ROBIS, and GRADE. Narrative synthesis was performed because of high heterogeneity.
resultsTwenty systematic reviews and meta-analyses covering a large number of human orthodontic trials were included. Low-certainty evidence suggests that LLLT/PBM may be associated with accelerated OTM, slight reductions in orthodontically induced inflammatory root resorption (OIIRR), and short-term pain relief. Vitamin D showed inconsistent findings across outcomes with no reliable overall clinical benefit.
conclusionsCurrent evidence is insufficient to recommend the routine clinical use of LLLT/PBM or vitamin D in orthodontics.
trial registrationPROSPERO CRD42024591253.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.