Evidence map›Paper›PMID 42464181›Full record

ArticleBMC pediatrics2026

Association between elevated blood glucose level and brain injuries (IVH/WMI) in preterm infants.

Renée Lampe, Ursula Felderhoff-Müser, Irina Sidorenko, Marcus Krüger, Eva Lück, Ekaterini Michales, Uwe Sassen, Christian Brickmann

Abstract read
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Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Renée Lampe *TUM School of Medicine and Health, Department of Orthopedics and Sport Orthopedics, Markus Würth Professorship at Technical University of Munich, Research Unit for Paediatric Neuroorthopedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Technical University of Munich, TUM University Hospital, Ismaninger Str. 22, Munich, 81675, Germany. renee.lampe@tum.de.
Ursula Felderhoff-Müser *Department of Paediatrics I, Neonatology, Paediatric Intensive Care, Paediatric Infectious Diseases, Paediatric Neurology, Centre for Translational Neuro- and Behavioural Sciences, University of Duisburg-Essen, University Hospital Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Irina SidorenkoTUM School of Medicine and Health, Department of Orthopedics and Sport Orthopedics, Research Unit for Paediatric Neuroorthopedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Technical University of Munich, TUM University Hospital, Ismaninger Str. 22, 81675, Munich, Germany.
Marcus KrügerClinic for Neonatology, Munich Clinic Harlaching & Schwabing, Sanatoriumsplatz 2, 81545, Munich, Germany.
Eva LückTUM School of Medicine and Health, Department of Orthopedics and Sport Orthopedics, Research Unit for Paediatric Neuroorthopedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Technical University of Munich, TUM University Hospital, Ismaninger Str. 22, 81675, Munich, Germany.
Ekaterini MichalesTUM School of Medicine and Health, Department of Orthopedics and Sport Orthopedics, Research Unit for Paediatric Neuroorthopedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Technical University of Munich, TUM University Hospital, Ismaninger Str. 22, 81675, Munich, Germany.
Uwe SassenTUM School of Medicine and Health, Department of Neonatology, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Christian BrickmannTUM School of Medicine and Health, Department of Pediatrics, Kinderklinik Muenchen Schwabing, Technical University of Munich, TUM University Hospital, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe likelihood of developing preterm brain injury such as intraventricular hemorrhage (IVH) or cystic white matter injury (cWMI) largely depends on gestational age. However, its pathogenesis is multifactorial, and accounting of additional risk factors is important for preventing brain injury. Glucose is one of the most important energy sources for the brain. Both high and low blood glucose level may be associated with the onset and progression of brain disorders.

methodsTo evaluate the relation between preterm brain injury (IVH/cWMI) and blood glucose level, univariate statistical analyses of retrospective data of 109 extremely and very preterm infants was performed. The analyzed data included 14 prenatal and infant diagnoses and 32 regularly measured parameters.

resultsMean values of whole blood glucose levels in preterm infants diagnosed with IVH or cWMI was higher than in controls indicating that elevated blood glucose level is associated with development of preterm brain injury. Mean values were higher both before and after diagnosis of IVH or cWMI, and even significantly exceeded the hyperglycemia threshold of 125 mg/dL following IVH diagnosis. Furthermore, a significant or moderate association was revealed between elevated blood glucose level and 8 medical diagnoses, as well as 21 routinely measured parameters.

conclusionOur study emphasizes the importance of regularly monitoring blood glucose levels in preterm infants and keeping it within a safe range.

Indexed as

Blood GlucoseBrain InjuriesHyperglycemiaInfant, Premature, DiseasesFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesRisk FactorsBlood GlucoseExtremely and very preterm infantsHyperglycemiaHypoglycemiaIntraventricular hemorrhageWhite matter injuryWhole blood glucose

Identifiers

PMID42464181
PMCPMC13383477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.