Evidence map›Paper›PMID 42464026›Full record

ReviewSocial cognitive and affective neuroscience2026

Review of methods to derive the heartbeat-evoked potential: past practices and future directions.

Rania-Iman Virjee, Rohan Kandasamy, Sarah N Garfinkel, David W Carmichael, Mahinda Yogarajah

Abstract readReview
In one paragraph

Review in Social cognitive and affective neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Model-based cardiac field artefact correction for OP-MEG.Imaging neuroscience (Cambridge, Mass.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rania-Iman VirjeeInstitute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London, WC1N 3AZ, United Kingdom.ORCID 0000-0001-5077-6200
Rohan KandasamyInstitute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London, WC1N 3AZ, United Kingdom.ORCID 0000-0001-8554-2658
Sarah N GarfinkelInstitute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London, WC1N 3AZ, United Kingdom.
David W CarmichaelSchool of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, United Kingdom.
Mahinda YogarajahDepartment of Clinical Neurophysiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, United Kingdom.

Funding

Biotechnology and Biological Sciences Research Council BB/T008709/1Wellcome Mental Health 226778/Z/22/ZWellcome Trust
6 · The paper itself

Abstract

The heartbeat-evoked potential (HEP) is an implicit, electrophysiological marker of cortical heartbeat processing and interoception, with increasing clinical relevance. However, on the scalp, HEP are low-amplitude signals mixed with cardiac field artefacts (CFA), requiring signal processing pipelines to separate HEP from CFA. This review evaluates current analytical approaches and addresses methodological gaps in HEP pipelines. A scoping review of the literature was conducted focusing on previously published HEP studies. This was to extract HEP processing methods and parameters used in EEG (199 included papers) and MEG (8 included papers). Parameters investigated included the HEP window, filters, baseline correction window, epoch timeframes, minimum RR intervals, epoch amplitude rejection threshold, and CFA removal. EEG and MEG studies revealed clear heterogeneity and variability in the methods used to derive HEP. These clear inconsistencies in HEP parameter use and reporting would appear to challenge the level replicability between studies. In order to ensure reproducibility and transparency, publications should report critical values for reliable HEP extraction, emphasizing the need for standardized methods to enhance study comparability and reproducibility.

Indexed as

BrainElectroencephalographyEvoked PotentialsHeart RateMagnetoencephalographyHumansInteroceptionReproducibility of ResultsSignal Processing, Computer-AssistedElectroencephalogram (EEG)Heartbeat-Evoked Potential (HEP)InteroceptionMagnetoencephalogram (MEG)Methodological approachesScoping review

Identifiers

PMID42464026
PMCPMC13585452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.