Evidence map›Paper›PMID 42463970›Full record

ArticleOphthalmology and therapy2026

180-Degree Nuclear Flip: A Safety and Efficacy Assessment of a Phacoemulsification Technique for Cataract Nuclei of Grade III and Below.

Ruibo Chen, Tao Xu, Guorong Shi, Chunyan Xi, Mengqing Yin, Kai Hu, Bing Chen

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Article in Ophthalmology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ruibo Chen *School of Medicine, Southeast University, Nanjing, 210009, China.
Tao Xu *Guanghua Optometry Eye Hospital, Changzhou, 213003, China.
Guorong Shi *Changzhou Health Vocational Technology College, Changzhou, 213002, China.
Chunyan XiPurui Eye Hospital, Changzhou, 213003, China.
Mengqing YinGuanghua Optometry Eye Hospital, Changzhou, 213003, China.
Kai HuDepartment of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, China. hukai70@163.com.
Bing ChenPurui Eye Hospital, Changzhou, 213003, China. chenbing751@126.com.ORCID http://orcid.org/0009-0003-5925-227X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis prospective randomized controlled trial aims to evaluate the effectiveness and safety of a 180° nuclear flip technique in phacoemulsification cataract surgery, comparing it with the traditional endocapsular approach for cataracts of Emery-Little grade III and below.

methodsA total of 142 patients were randomly assigned to either the 180° nuclear flip group (n = 71) or the conventional endocapsular phacoemulsification group (n = 71). The primary outcomes measured were total phacoemulsification time (TPT) and effective phacoemulsification time (EPT). Secondary outcomes were the incidence of postoperative corneal endothelial cell loss (ECL) at 7 and 28 days, as well as intraoperative complications including posterior capsule rupture (PCR).

resultsThe mean TPT was substantially shorter in the flip group (43.75 ± 17.16 s) compared to the conventional group (58.45 ± 22.27 s) (P < 0.0001). Similarly, the mean EPT was also significantly reduced in the flip group (11.08 ± 5.25 s vs. 14.87 ± 8.54 s, P = 0.0046). There were no PCR cases in the flip group, whereas there was one case (1.4%) in the traditional group. At 28 days postoperatively, the mean ECL rate of the flip group (3.7%) was lower than that of the conventional group (4.9%), although this difference did not reach statistical significance.

conclusionThe 180° nuclear flip technique is a safe, efficient, and effective method for managing cataracts of grade III hardness and below. It may help reduce the risk of complications, improves intraoperative stability by creating a more spacious operating field, and significantly reduces phacoemulsification time. Video available for this article.

trial registrationchictr.org.cn identifier, ChiCTR2500105241.

Indexed as

Cataract surgeryEndothelial cell lossNuclear flipPhacoemulsificationRandomized controlled trial

Identifiers

PMID42463970
PMCPMC13518638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.