Evidence map›Paper›PMID 42463960›Full record

ArticleNpj mental health research2026

Mendelian randomization of risk factors for premenstrual disorders.

Yihui Yang, Bowen Tang, Elgeta Hysaj, Nanyan Xiang, Susu Qu, Sara Hägg, Unnur A Valdimarsdóttir, Elizabeth Bertone-Johnson, Yi Lu, Donghao Lu

Abstract read
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In one paragraph

Article in Npj mental health research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yihui YangInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. yihui.yang.2@ki.se.
Bowen TangInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Elgeta HysajInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nanyan XiangHealth Management Center, General Practice Medical Center, Lab of Health Data Science, Innovation Institute for Integration of Medicine and Engineering, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Susu QuInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Unnur A ValdimarsdóttirInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Elizabeth Bertone-JohnsonDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Yi LuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Donghao LuInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. donghao.lu@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causal role of established risk factors for premenstrual disorders (PMDs) remains unclear. We used Mendelian randomization (MR) to assess causality for eight known-risk factors identified through a literature review. Summary statistics for these risk factors were from genome-wide association studies (GWAS) with sample size ranging from 129,017 to 1.2 million, and for PMDs from a GWAS of 72,297 participants. Findings were validated using one-sample MR in LifeGene cohort (n = 5674-5937). In two-sample MR, genetic liability to smoking initiation (OR = 1.25 (1.10-1.43)), earlier menarche (OR = 0.94 (0.89-0.98) per year), and higher BMI (OR = 1.19 (1.05-1.34) per kg/m

Identifiers

PMID42463960
PMCPMC13376395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.