Evidence map›Paper›PMID 42463919›Full record

ArticleActa pharmacologica Sinica2026

Peripheral somatostatin-expressing neurons are analgesic targets for refractory occipital neuralgia.

Qiong Wang, Chen Li, Qian-Wen Zhu, Teng-Fei Liu, Guo-Dun Zhao, Yi-Fan Tang, Ye Jiang, Zi-Xian Chen, Jing Feng, Yong Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiong Wang *State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Chen Li *Department of Neurosurgery, National Medical Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Qian-Wen ZhuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Teng-Fei LiuDepartment of Neurosurgery, National Medical Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Guo-Dun ZhaoUniversity of Chinese Academy of Sciences, Beijing, 100049, China.
Yi-Fan TangDepartment of Neurosurgery, Shanghai Geriatric Medical Center, Shanghai, 201104, China.
Ye JiangDepartment of Neurosurgery, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Zi-Xian ChenDepartment of Orthopedics, National Medical Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jing FengUniversity of Chinese Academy of Sciences, Beijing, 100049, China. fengjing@simm.ac.cn.
Yong YuDepartment of Neurosurgery, National Medical Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. yuyongziming@163.com.
Zhao-Bing GaoState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. zbgao@simm.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Occipital neuralgia (ON) is a refractory chronic headache disorder characterized by paroxysmal shooting or stabbing pain in the posterior scalp, innervated by occipital nerves that originate from C2 and C3 dorsal root ganglion (DRG) neurons. Limited access to human DRG samples has impeded the understanding of the cellular and molecular mechanisms and the development of effective treatments for ON. We innovatively employed percutaneous full-endoscopic C2 ganglionectomy and subsequently performed single-nucleus RNA-sequencing (snRNA-seq) on C2 DRG from both ON patients and healthy controls. Somatostatin-expressing (SST

Indexed as

Ganglia, SpinalNeuralgiaNeuronsSomatostatinAnimalsFemaleGanglionectomyHumansMaleMiceMice, Inbred C57BLOptogeneticsSomatostatindorsal root gangliaoccipital neuralgiasingle-nucleus RNA-sequencingsomatostatin-expressing neurons

Identifiers

PMID42463919
PMCPMC13586197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.