Evidence map›Paper›PMID 42463910›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Temporal enhancement patterns on 3D-FLAIR MRI in labyrinthine infarction.

Hyun Sung Kim, Eun Hye Oh, Jieun Roh, Seung-Kug Baik, Seo Young Choi, Kwang-Dong Choi, Jae-Hwan Choi

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Hyun Sung KimDepartment of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Kumo-ro 20, Beomo-ri, Mulgum-eup, Yangsan, Gyeongnam, 50612, South Korea.
Eun Hye OhDepartment of Neurology, Seo Il Medical Group Clinic, Busan, South Korea.
Jieun RohDepartment of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Seung-Kug BaikDepartment of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Seo Young ChoiDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Kwang-Dong ChoiDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Jae-Hwan ChoiDepartment of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Kumo-ro 20, Beomo-ri, Mulgum-eup, Yangsan, Gyeongnam, 50612, South Korea. rachelbolan@hanmail.net.ORCID http://orcid.org/0000-0002-4120-9228

Funding

Pusan National University Yangsan Hosptial 30-2022-008
6 · The paper itself

Abstract

backgroundInner ear enhancement on contrast-enhanced three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) MRI reflects disruption of the blood-labyrinth barrier (BLB) and has been reported in several audiovestibular disorders. However, the temporal enhancement pattern in labyrinthine infarction remains poorly characterized.

methodsWe investigated time-dependent enhancement patterns on 3D-FLAIR MRI in four patients with labyrinthine infarction secondary to anterior inferior cerebellar artery infarction. All patients underwent comprehensive neuro-otological evaluation and contrast-enhanced inner ear MRI. Axial 3D-FLAIR images were obtained at three time points: pre-contrast, 10 min, and 4 h after gadolinium administration. Enhancement patterns were compared with those observed in 37 patients with non-vascular audiovestibular disorders, including sudden sensorineural hearing loss with vertigo ( n = 3), Ménière's disease (n = 9), recurrent vestibulopathy (n = 14), acute unilateral vestibulopathy (n = 11), who underwent the same imaging protocol.

resultsAll four patients with labyrinthine infarction demonstrated ipsilesional enhancement of both the cochlea and vestibule on 4-hour delayed images. Two patients also showed early enhancement confined to the cochlea on 10-minute images. By contrast, only 8 of 37 patients (22%) with non-vascular audiovestibular disorders demonstrated enhancement, which was predominantly observed on 4-hour delayed images but not detected on 10-minute images.

conclusionsThese findings suggest that 4-hour delayed enhancement is a consistent imaging feature of labyrinthine infarction, whereas early (10-minute) enhancement may occur in a subset of patients and may provide insight into the temporal evolution of BLB disruption following ischemic injury.

Indexed as

Ear, InnerImaging, Three-DimensionalInfarctionLabyrinth DiseasesMagnetic Resonance ImagingAdultAgedFemaleHumansMaleMiddle AgedTime Factors3D-FLAIR MRIBlood-labyrinth barrierLabyrinthine infarction

Identifiers

PMID42463910

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