Evidence map›Paper›PMID 42463865›Full record

ArticleNature structural & molecular biology2026

Conformational plasticity of human acid-sensing ion channel 1a.

James Cahill, Kimberly A Hartfield, Stephanie Andrea Heusser, Nadine Ritter, Mette Homann Poulsen, Craig Yoshioka, Stephan Alexander Pless, Isabelle Baconguis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Conformational plasticity of human acid-sensing ion channel 1a.Nature structural & molecular biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

James Cahill *Vollum Institute, Oregon Health and Science University, Portland, OR, USA.
Kimberly A Hartfield *Vollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-7290-5648
Stephanie Andrea HeusserDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Nadine RitterDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2749-885X
Mette Homann PoulsenDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Craig YoshiokaDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Stephan Alexander PlessDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6654-114X
Isabelle BaconguisVollum Institute, Oregon Health and Science University, Portland, OR, USA. bacongui@ohsu.edu.ORCID http://orcid.org/0000-0002-5440-2289

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acid-sensing ion channels (ASICs) are typically activated by acidic environments and contribute to nociception and synaptic plasticity. ASIC1a is the most abundant subunit in the central nervous system and forms homomeric channels permeable to Na

Indexed as

Acid Sensing Ion ChannelsCryoelectron MicroscopyHumansHydrogen-Ion ConcentrationIon Channel GatingModels, MolecularProtein ConformationAcid Sensing Ion ChannelsASIC1 protein, human

Identifiers

PMID42463865
PMCPMC13468109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.