Evidence map›Paper›PMID 42463709›Full record

ArticleNature communications2026

Cooperative mechanism of neurotransmitter recognition and transport by the human vesicular polyamine transporter.

Yi Guo, Ge Yang, Jin Chai, John Shanklin, Bin Liu, Min Lu

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Guo *Center for Proteomics & Molecular Therapeutics, Rosalind Franklin University of Medicine & Science, North Chicago, IL, USA.
Ge Yang *The Hormel Institute, University of Minnesota, Austin, MN, USA.ORCID http://orcid.org/0000-0002-5085-4261
Jin Chai *Biology Department, Brookhaven National Laboratory, Upton, NY, USA.ORCID http://orcid.org/0000-0002-4760-5811
John ShanklinBiology Department, Brookhaven National Laboratory, Upton, NY, USA.ORCID http://orcid.org/0000-0002-6774-8043
Bin LiuThe Hormel Institute, University of Minnesota, Austin, MN, USA. liu00794@umn.edu.ORCID http://orcid.org/0000-0002-6581-780X
Min LuCenter for Proteomics & Molecular Therapeutics, Rosalind Franklin University of Medicine & Science, North Chicago, IL, USA. min.lu@rosalindfranklin.edu.ORCID http://orcid.org/0000-0002-3596-7559

Funding

Molecular Basis of Substrate Translocation in the Drug/H+ Antiporter 1 FamilyR01GM145642 · NIGMS · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI LU, MIN · 2022 to 2025
$1.3M
NIGMS NIH HHS R01 GM145642U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM145642
6 · The paper itself

Abstract

Human vesicular polyamine transporter (hVPAT) from the SLC18 antiporter family sequesters polyamine neuromodulators into secretory vesicles in exchange for H

Indexed as

AntiportersHistamineNeurotransmitter AgentsSerotoninBinding SitesBiological TransportCryoelectron MicroscopyHumansLiposomesModels, MolecularPolyaminesProtein BindingAntiportersHistamineLiposomesNeurotransmitter AgentsPolyaminesSerotonin

Identifiers

PMID42463709
PMCPMC13490608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.