Evidence map›Paper›PMID 42463668›Full record

ArticleNature communications2026

Reconstitution of Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputs.

Sophia Doerr, Andrés Olavarrieta Colasurdo, Scott D Hansen

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sophia DoerrInstitute of Molecular Biology, University of Oregon, Eugene, OR, USA.ORCID http://orcid.org/0000-0003-4551-0357
Andrés Olavarrieta ColasurdoInstitute of Molecular Biology, University of Oregon, Eugene, OR, USA.ORCID http://orcid.org/0009-0009-7969-0561
Scott D HansenInstitute of Molecular Biology, University of Oregon, Eugene, OR, USA. shansen5@uoregon.edu.ORCID http://orcid.org/0000-0001-7005-6200

Funding

Deciphering the mechanism of SHIP1 regulation in human neutrophilsR01GM143406 · NIGMS · UNIVERSITY OF OREGON · PI HANSEN, SCOTT DAVID · 2021 to 2025
$1.7M
National Science Foundation (NSF) CAREER MCB-2048060NIGMS NIH HHS R01 GM143406U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01 GM143406
6 · The paper itself

Abstract

Reactions involving small GTPases and phosphatidylinositol phosphate (PIP) lipids serve essential roles in signal transduction at the plasma membrane. In cells, these distinct classes of molecules are linked through positive and negative feedback loops that give rise to emergent properties such as excitability and polarization. Here, we reconstitute communication and feedback between Ras GTPase and phosphatidylinositol 3-kinase gamma (PI3Kγ)-mediated PIP

Indexed as

Cell MembraneClass Ib Phosphatidylinositol 3-KinaseFeedback, Physiologicalras ProteinsSignal TransductionAnimalsGuanosine TriphosphateHumansLightPhosphatidylinositol PhosphatesClass Ib Phosphatidylinositol 3-KinaseGuanosine TriphosphatePhosphatidylinositol Phosphatesras Proteins

Identifiers

PMID42463668
PMCPMC13490392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.