Evidence map›Paper›PMID 42463655›Full record

ArticleNature communications2026

Saxiphilin functions as a toxin sponge protein that counteracts the effects of saxitoxin poisoning.

Samantha A Nixon, Sandra Zakrzewska, Seil Jang, Keli Huang, Anissa Bara, Zhou Chen, Daynen R Goss, Elizabeth R Park, J Du Bois, Daniel L Minor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Samantha A Nixon *Cardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID 0000-0003-3157-4114
Sandra Zakrzewska *Cardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID 0000-0002-8706-4394
Seil JangCardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID 0009-0000-6816-5635
Keli HuangCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Anissa BaraSophion Bioscience, Ballerup, Denmark.ORCID 0000-0002-5721-2675
Zhou ChenCardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID 0000-0002-4426-2497
Daynen R GossDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Elizabeth R ParkDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9974-3899
J Du BoisDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7847-1548
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, CA, USA. daniel.minor@ucsf.edu.ORCID 0000-0002-5998-4214

Funding

Guanidinium Toxins as Molecular Probes for NaV StudyR01GM117263 · NIGMS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2016 to 2024
$3.5M
NIGMS NIH HHS R01 GM117263United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA 1 19 1-0040United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA 1 21 1 0011United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA-1-23-1-0026U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) NIGMS R01 GM117263 05
6 · The paper itself

Abstract

Saxitoxin (STX) is among the most potent toxins known, is classified as a chemical weapon, and is the archetype of the paralytic shellfish toxin (PST) family produced by marine and freshwater harmful algal blooms (HAB). STX causes paralysis and death through inhibition of voltage-gated sodium channels (Na

Indexed as

SaxitoxinShellfish PoisoningAnimalsFemaleHarmful Algal BloomMiceSaxitoxin

Identifiers

PMID42463655
PMCPMC13376186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.