Evidence map›Paper›PMID 42463608›Full record

ArticleAnnals of surgical oncology2026

Risk of Ovarian Metastasis in Colorectal Cancer-Related Carcinomatosis.

Ryan B Morgan, Taylor Neilson, Stephanie Keeling, LaDonna Kearse, Kilian Brown, Megan Delisle, Kentaro Ochiai, Beth Helmink, Yun Song, Jason Willis and 22 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Ryan B MorganDivision of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Taylor NeilsonDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Stephanie KeelingDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
LaDonna KearseDivision of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kilian BrownDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Megan DelisleDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kentaro OchiaiDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Beth HelminkDivision of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yun SongDivision of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jason WillisCancer Medicine Division, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
John Paul ShenCancer Medicine Division, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Ian HuCancer Medicine Division, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Victoria S HigbieCancer Medicine Division, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Jarett FeldmanCancer Medicine Division, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Van MorrisCancer Medicine Division, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Kasey MaturaDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Santosh SadasivanDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Y Nancy YouDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brian BednarskiDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tsuyoshi KonishiDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ramy BehmanDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jenny MoonDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Craig MessickDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Montserrat Guraieb-TruebaDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jagan RamamurthyDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Miguel Rodriguez-BigasDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
George J ChangDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J Joshua SmithDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Paul MansfieldDivision of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Keith FournierDivision of Surgery, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael G WhiteDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Paula Marincola SmithDivision of Surgery, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA. psmith7@mdanderson.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn colorectal cancer (CRC)-related carcinomatosis, the risk of ovarian metastases (OM) is not well described, and practices during cytoreductive surgery (CRS) vary widely. Defining this risk is critical for counseling patients on the necessity of oophorectomy during CRS.

methodsThis retrospective study analyzed female patients with CRC-related carcinomatosis undergoing curative intent CRS with or without hyperthermic intraperitoneal chemotherapy (HIPEC) at a single center (2008-2024).

resultsThe study identified 74 patients, 66% of whom were post-menopausal. The median Peritoneal Cancer Index (PCI) was 8 (interquartile range [IQR], 6-10), and all the patients had a complete cytoreduction (CCR 0/1). Right-sided primary tumors were the most common (57%), and the histology was most commonly non-mucinous (n = 51, 69%), moderately differentiated (n = 49, 66%), and microsatellite stable (n = 67, 90%). Neoadjuvant therapy was common (n = 58, 78%), and 25 (34%) of the patients underwent HIPEC. Four of the patients (5%) had undergone bilateral salpingo-oophorectomy (BSO) before the diagnosis of peritoneal disease. Of the 70 remaining patients, 51 (73%) had grossly abnormal-appearing ovaries. Of the 70 patients, 65 (93%) had a bilateral or completion salpingo-oophorectomy, and 2 (3%) underwent a unilateral oophorectomy. Overall, 55 (79%) of the patients had pathologically confirmed OM. Of the 16 patients with normal-appearing ovaries who underwent oophorectomy, 4 (25%) had microscopic OM. Two (40%) of the five patients with normal-appearing ovaries preserved during CRS experienced ovarian recurrence within 15 months.

conclusionsMost of the female patients undergoing CRS for CRC-related carcinomatosis had OM, including 25% of the patients with normal-appearing ovaries. Short-interval recurrence was observed with ovarian preservation. Routine BSO should be strongly considered for patients undergoing CRS with curative intent.

Indexed as

Colorectal cancerCytoreductive surgeryHIPECOvarian metastasisPeritoneal carcinomatosis

Identifiers

PMID42463608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.