Evidence map›Paper›PMID 42463583›Full record

ArticleJournal of gastroenterology2026

Neoadjuvant and adjuvant treatment for pancreatic ductal adenocarcinoma in patients over 80 years old based on a nationwide clinical database.

Daisuke Hashimoto, Shinya Hirakawa, Masamichi Mizuma, Hisateru Tachimori, So Yamaki, Takao Itoi, Shinichi Egawa, Yuzo Kodama, Kohei Nakata, Shin Hamada and 7 more

Abstract read
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Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Daisuke HashimotoDepartment of Pancreatobiliary Surgery, Kansai Medical University, 2-5-1 Shin-Machi, Hirakata City, Osaka, 573-1010, Japan. daisukeh007@gmail.com.ORCID http://orcid.org/0000-0002-7880-889X
Shinya HirakawaEndowed Course for Health System Innovation, Keio University School of Medicine, Shinjuku, Japan.
Masamichi MizumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hisateru TachimoriEndowed Course for Health System Innovation, Keio University School of Medicine, Shinjuku, Japan.
So YamakiDepartment of Pancreatobiliary Surgery, Kansai Medical University, 2-5-1 Shin-Machi, Hirakata City, Osaka, 573-1010, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Japan.
Shinichi EgawaDivision of International Cooperation for Disaster Medicine, Tohoku University, Sendai, Japan.
Yuzo KodamaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kohei NakataDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shin HamadaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ichiro YasudaThird Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoshihiro KakejiDivision of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Ken ShirabeDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
Sohei SatoiDepartment of Pancreatobiliary Surgery, Kansai Medical University, 2-5-1 Shin-Machi, Hirakata City, Osaka, 573-1010, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoshifumi TakeyamaDepartment of Surgery, Kindai University Faculty of Medicine, Osakasayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe proportion of elderly patients with pancreatic ductal adenocarcinoma (PDAC) is increasing. This study aimed to investigate whether neoadjuvant treatment (NAT) and adjuvant therapy (AT) are effective in PDAC patients over 80 years of age.

methodsPatients over 80 years of age who underwent pancreatectomy for PDAC in 2012-2020 and were recorded in the Japan Society for Gastroenterological Surgery and Japan Pancreas Society databases were included. Propensity score matching (PSM) analysis was performed to determine whether NAT and AT contribute to survival. In patients treated from 2017 onward, resectability status was incorporated into the PSM model.

resultsOf the 3438 patients in the study population, the primary resectability-adjusted PSM analysis of NAT among patients treated from 2017 onward compared 274 matched pairs. The MST was 30.5 (95% CI, 26.2-NA) and 29.0 (95% CI, 22.3-38.0) months in the NAT and non-NAT groups, respectively, with no significant difference (p = 0.205 [stratified log-rank]). In a complementary full-cohort PSM analysis, 393 matched pairs were compared; the MST was 32.9 and 30.2 months, respectively, with no significant difference. In a PSM-matched comparison of 1213 patients who received AT versus 1213 patients who did not, MST was longer in the former (30.7 [95% CI, 27.3-33.2] versus 23.7 [95% CI, 21.8-26.1] months, p < 0.001 [stratified log-rank]).

conclusionNAT did not show a statistically significant survival benefit in PDAC patients aged 80 years or older, however, this finding should be interpreted with caution. In contrast, AT was associated with improved survival.

Indexed as

Elderly patientsNeoadjuvant treatmentPancreatectomyPancreatic ductal adenocarcinomaSurgery

Identifiers

PMID42463583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.