Evidence map›Paper›PMID 42463512›Full record

ArticleNature communications2026

Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia.

Eugenia Radulescu, Petra E Vértes, Shizhong Han, Jennifer A Erwin, Apuã C M Paquola, Thomas M Hyde, Joel E Kleinman, Tomoyo Sawada, Edward T Bullmore, Daniel R Weinberger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eugenia RadulescuLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA. eugenia.radulescu@libd.org.ORCID http://orcid.org/0000-0002-3924-768X
Petra E VértesDepartment of Psychiatry, University of Cambridge Clinical School, Cambridge, UK.ORCID http://orcid.org/0000-0002-0992-3210
Shizhong HanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-5114-6742
Jennifer A ErwinAluco BioSciences, San Carlos, USA.ORCID http://orcid.org/0000-0002-6784-9290
Apuã C M PaquolaDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Thomas M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-8746-3037
Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-4210-6052
Tomoyo SawadaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-2280-6238
Edward T BullmoreDepartment of Psychiatry, University of Cambridge Clinical School, Cambridge, UK.ORCID http://orcid.org/0000-0002-8955-8283
Daniel R WeinbergerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA. drweinberger@libd.org.ORCID http://orcid.org/0000-0003-2409-2969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysconnectivity in schizophrenia is a pervasive concept across various levels of systems biology. To better understand disrupted patterns of molecular connectivity in schizophrenia, we apply innovative approaches to gene co-expression networks starting from multiple regions of postmortem brain (bulk RNA-Seq from dorso-lateral prefrontal cortex- (DLPFC) (N

Indexed as

Gene Regulatory NetworksNeuronsOligodendrogliaSchizophreniaBrainDorsolateral Prefrontal CortexFemaleGene Expression ProfilingHippocampusHumansInduced Pluripotent Stem CellsMale

Identifiers

PMID42463512
PMCPMC13494048

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.