Trial reportThe Kobe journal of medical sciences2026
Effects of Rocuronium on Ischemia-reperfusion Injury and Intracellular ATP Consumption: A Randomized Controlled Trial.
Trial report in The Kobe journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundMuscle relaxants reduce "total" oxygen consumption, and 1.2 mg/kg of rocuronium has been shown to attenuate ischemia-reperfusion injury (IRI). Therefore, we herein investigated whether 0.9 mg/kg of rocuronium reduced "local" oxygen consumption and IRI indirectly by measuring changes in hypoxanthine (HPX), an indicator of intracellular adenosine triphosphate (ATP) consumption, and malondialdehyde (MDA), an indicator of IRI, respectively.
methodsThis study was designed as a randomized controlled trial. Female patients aged 50-79 years old who were scheduled for elective knee arthroplasty under general anesthesia were recruited. After the collection of pre-ischemia blood samples, 0.9 mg/kg of rocuronium was administered to patients in group R and a placebo to those in group C 3 minutes before tourniquet inflation. Five minutes after tourniquet deflation, post-ischemia blood samples were collected. The primary outcome was the change in the concentration of MDA (Δ MDA) after ischemia.
resultsMedians [interquartile ranges] for Δ MDA (μmol/L) in group R (n = 19) and group C (n = 18) were -0.47 [-1.25 to 0.13] and -0.58 [-0.67 to -0.28], respectively, with no significant difference (
conclusionsWe were unable to confirm that 0.9 mg/kg of rocuronium attenuates IRI or postoperative quadriceps muscle weakness. While the present results suggest that rocuronium reduced intracellular ATP consumption, no clinically beneficial effects were observed.
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