Evidence map›Paper›PMID 42462993›Full record

ArticleEnvironmental research2026

Exposure to legacy and replacement PFAS including perfluorobutanesulfonic acid (PFBS) in a New York City-based pregnancy cohort.

Eleanor A Medley, Duong Q Nguyen, Anne E Nigra, Amy M Padula, Carin A Huset, Kitrina M Barry, Lisa A Peterson, Vittorio Albergamo, Mengling Liu, Akhgar Ghassabian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eleanor A MedleyDepartment of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY, USA. Electronic address: eleanor.medley@nyulangone.org.
Duong Q NguyenDepartment of Pediatrics, New York University Grossman School of Medicine, Translational Research Building 227 E 30th St, New York, NY, USA.
Anne E NigraDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 W 168th St, New York, NY, USA.
Amy M PadulaDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, 550 16th St, San Francisco, CA, USA.
Carin A HusetMinnesota Human Health Exposure Analysis Resource (HHEAR) Targeted Analysis Laboratory, Minnesota Department of Health, 625 Robert St N, St. Paul, MN, USA.
Kitrina M BarryMinnesota Human Health Exposure Analysis Resource (HHEAR) Targeted Analysis Laboratory, Minnesota Department of Health, 625 Robert St N, St. Paul, MN, USA.
Lisa A PetersonMinnesota Human Health Exposure Analysis Resource (HHEAR) Targeted Analysis Laboratory, Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, 2231 6th St SE, Minneapolis, MN, USA.
Vittorio AlbergamoDepartment of Pediatrics, New York University Grossman School of Medicine, Translational Research Building 227 E 30th St, New York, NY, USA.
Mengling LiuDepartment of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY, USA.
Akhgar GhassabianDepartment of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, Translational Research Building 227 E 30th St, New York, NY, USA.
Linda G KahnDepartment of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, Translational Research Building 227 E 30th St, New York, NY, USA.
Leonardo TrasandeDepartment of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, Translational Research Building 227 E 30th St, New York, NY, USA.
Whitney CowellDepartment of Population Health, New York University Grossman School of Medicine, 180 Madison Ave, New York, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, Translational Research Building 227 E 30th St, New York, NY, USA.

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Untargeted Analysis ResourceU2CES026533 · NIEHS · UNIVERSITY OF MINNESOTA · PI PETERSON, LISA A · 2015 to 2025
$14.0M
NIEHS NIH HHS U2C ES026533NIH HHS U2C OD023375NIH HHS UH3 OD023305
6 · The paper itself

Abstract

Relatively few epidemiologic studies in the US have measured the short-chain replacement per- or polyfluoroalkyl substance (PFAS) perfluorobutanesulfonic acid (PFBS), and little is known about its health impacts. We measured prenatal serum concentrations of 13 PFAS, including PFBS, among 500 participants in the New York University Children's Health and Environment Study (NYU CHES) between 2016 and 2019. We investigated associations of PFAS exposures with demographic characteristics, including location of residence, and conducted an exploratory factor analysis to investigate common sources of exposure. PFBS concentrations were quantified in 95.6% of samples (median 0.40 ng/mL), which was unexpectedly higher than serum PFBS concentrations reported in other US-based cohorts. PFBS concentrations were not correlated with other PFAS, though they were positively correlated with each other. Unlike other PFAS, PFBS concentrations were not associated with participant characteristics, and there was no evidence for spatial autocorrelation. The changing PFAS exposure landscape warrants further investigation into the health effects of short-chain replacements, particularly in vulnerable populations.

Indexed as

Environmental PollutantsFluorocarbonsMaternal ExposureSulfonic AcidsAdultCohort StudiesFemaleHumansNew York CityPregnancyEnvironmental PollutantsFluorocarbonsperfluorobutanesulfonic acidSulfonic Acids

Identifiers

PMID42462993
PMCPMC13472197

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.