Evidence map›Paper›PMID 42462396›Full record

ArticleJournal of Ayurveda and integrative medicine

Symphytum officinale enhances fracture healing in Wistar albino rats by promoting osteogenesis in fracture callus.

S Tyagi, P K Pagaku, V Shrivastava, D Dey, A Aryal, A Bhattacharya, S Rani, B Garg, P Khanna, A Goyal and 4 more

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Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

S TyagiDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
P K PagakuDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
V ShrivastavaDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
D DeyDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
A AryalDepartment of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.
A BhattacharyaDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
S RaniDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
B GargDepartment of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.
P KhannaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
A GoyalDepartment of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India.
D NayakCentral Council for Research in Homoeopathy, New Delhi, India.
R K SrivastavaDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
A R MridhaDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.
S SenDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India. Electronic address: sudipsen665@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSymphytum officinale (SO) is a medicinal plant. This study investigated if homoeopathic doses of SO could enhance fracture healing in adult male Wistar albino rats after induction of fracture.

methodsAdult male Wistar albino rats underwent open osteotomy (femur), were divided into various treatment groups and received homoeopathic doses of oral SO (mother tincture (MT) and 6C), vehicle control and standard care (control). X-ray imaging and serum analysis evaluated fracture healing. The rats were sacrificed at two time points: at 2 weeks (radiological appearance of early-soft callus) and at 5 weeks (late-hard callus). The fracture callus was evaluated with H&E staining, quantitative bone morphometry, and immunohistochemistry. Bone-specific Alkaline phosphatase (B-ALP), and C-terminal telopeptide of type I collagen (CTX) were evaluated in serum using ELISA.

resultsX-rays showed faster formation of callus (both soft and hard callus) in groups treated with MT and 6C doses of oral SO. Quantitative bone morphometry indicated enhanced osteogenesis in both soft (early) and hard (late) callus in animals treated with MT and 6C doses of SO. Immunohistochemical evaluation of soft (early) and hard (late) callus for Col1A1 and Osteocalcin revealed supporting osteogenic mechanisms. Serum levels of B- ALP and CTX indicated osteoanabolic activity in rats treated with the MT dose of SO.

conclusionsOral administration of homoeopathic doses of Symphytum officinale (especially mother tincture dose), has the potential to enhance fracture healing in adult male Wistar albino rats.

Indexed as

Alternative medicinePlant medicinal productWound healing promoting agent

Identifiers

PMID42462396
PMCPMC13400945

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