ArticleObstetrics and gynecology2026
Child Neurodevelopmental Outcomes After Late Preterm Hypoglycemia.
Cynthia Gyamfi-Bannerman, Jessica A de Voest, Alan T N Tita, Sean C Blackwell, Monica Longo, Rebecca G Clifton, T Michael O'Shea, Sabine Z Bousleiman, Felecia Ortiz, Dwight J Rouse and 11 more
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In one paragraphArticle in Obstetrics and gynecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
21 authors.
Cynthia Gyamfi-BannermanColumbia University, New York, New York; the University of California, San Diego, La Jolla, and Stanford University, Stanford, California; the George Washington University Biostatistics Center, Washington, DC; the University of Alabama at Birmingham, Birmingham, Alabama; the University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, the University of Texas Medical Branch, Galveston, and the University of Texas at Austin, Austin, Texas; the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; the University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina; Brown University, Providence, Rhode Island; the University of Utah Health Sciences Center, Salt Lake City, Utah; Eastern Virginia Medical School at Old Dominion University, Norfolk, Virginia; The Ohio State University, Columbus, and MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio; the University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado; and Northwestern University, Chicago, Illinois.
Jessica A de Voest
Alan T N Tita
Sean C Blackwell
Monica Longo
Rebecca G Clifton
T Michael O'Shea
Sabine Z Bousleiman
Felecia Ortiz
Dwight J Rouse
Torri D Metz
George R Saade
Kara M Rood
Kent D Heyborne
John M Thorp
Geeta K Swamy
William A Grobman
Kelly S Gibson
Yasser Y El-Sayed
George A Macones
for the
Eunice Kennedy Shriver
National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Funding
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2MMaternal-Fetal Medicine Units (MFMU) NetworkUG1HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Noelia Milena Modad Zork · 2016 to 2026
$3.6MNICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040544 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI Kelly S Gibson, Angela C. Ranzini · 2016 to 2026
$3.5MMaternal-Fetal Medicine Units Network -- The Northwestern Study CenterUG1HD040512 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Lynn M Yee · 2016 to 2026
$3.4MNICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040500 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI DWIGHT J ROUSE · 2016 to 2026
$3.4MUofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical CentersUG1HD034208 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Torri D Metz · 2016 to 2026
$3.4MNICHD Maternal Fetal Medicine Units NetworkUG1HD027915 · NICHD · OHIO STATE UNIVERSITY · PI Maged Costantine · 2016 to 2026
$3.3MUNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical StudiesUG1HD040560 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI John M Thorp · 2016 to 2026
$3.3MNICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040545 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hector Mendez-Figueroa · 2016 to 2026
$3.2MNICHD Maternal-Fetal Medicine Units NetworksUG1HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALAN THEVENET N. TITA · 2016 to 2026
$3.0MNICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD053097 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PACHECO, LUIS D · 2016 to 2024
$2.5MNICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD068258 · NICHD · DUKE UNIVERSITY · PI SWAMY, GEETA K. · 2016 to 2020
$87kNational Institute of Child Health and Human Development UG1 HD40485, U24 HD36801, UG1 HD27869, UG1 HD40545, UG1 HD40500, UG1 HD34208, UG1 HD53097, UG1 HD27915, UG1 HD68282, UG1 HD40560, UG1 HD68258, UG1 HD40512, UG1 HD40544, UG1 HD68268NICHD NIH HHS U24 HD036801NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD040500NICHD NIH HHS UG1 HD040512NICHD NIH HHS UG1 HD040544NICHD NIH HHS UG1 HD040545NICHD NIH HHS UG1 HD040560NICHD NIH HHS UG1 HD053097NICHD NIH HHS UG1 HD068258NICHD NIH HHS UG1 HD068268NICHD NIH HHS UG1 HD068282
6 · The paper itselfAbstract
objectiveTo evaluate whether hypoglycemia in neonates born to mothers at risk for late preterm delivery was related to adverse effects on childhood neurodevelopment.
methodsThis was a prospective follow-up study of children aged 6 years or older whose mothers were enrolled in the Antenatal Late Preterm Steroids multicenter randomized trial. The study was conducted at 13 centers that participated in the Maternal-Fetal Medicine Units Network cycle from 2011 to 2016. Follow-up was from 2017 to 2022. Adult consent and child assent were obtained. The primary exposure was hypoglycemia , defined as a blood glucose concentration less than 40 mg/dL within 24 hours of birth. The primary outcome, proportion of GCA (General Conceptual Ability) scores lower than 85 (-1 SD) from the DAS-II (Differential Ability Scales, 2nd Edition), was analyzed by the presence of hypoglycemia at birth, irrespective of initial trial treatment assignment (betamethasone or placebo). Secondary outcomes included GMFCS (Gross Motor Function Classification System) level, SRS-2 (Social Responsiveness Scale, 2 nd Edition) scores, and CBCL (Child Behavior Checklist) scores. Univariable and multivariable analyses were performed, the latter adjusted for prespecified variables known to be associated with the primary outcome.
resultsOf 1,026 children enrolled, 1,020 (99.4%) had blood glucose data and 944 had data for the primary outcome. Of these 944, 785 (83.2%) were delivered late preterm and 208 (22.0%) had hypoglycemia, of whom 84 (40.4%) were treated. Those with hypoglycemia were more likely to have private insurance, have older mothers, receive betamethasone, and identify as White. There were no differences in the primary outcome, GCA score lower than 85 (15.9% in those with hypoglycemia vs 18.5% in those without; adjusted relative risk 1.03; 95% CI, 0.74-1.45), and no difference in secondary outcomes. Severity of hypoglycemia also was not associated with any outcomes.
conclusionIn our cohort, hypoglycemia was not associated with neurodevelopmental outcomes in children born predominantly late preterm.
Identifiers
PMID42462244
PMCPMC13529302
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