Evidence map›Paper›PMID 42461856›Full record

ArticlePloS one2026

Bone-conducted ultrasonic auditory brainstem response thresholds in a mouse model of cisplatin-induced hearing loss.

Akihito Nakanishi, Noriko Nagase, Hirokazu Kousaki, Bakushi Ogawa, Kazuhiro Horii, Iori Niitsu Morimoto, Yuka Morita, Fumiaki Nin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Akihito NakanishiDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.
Noriko NagaseDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.
Hirokazu KousakiDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.
Bakushi OgawaDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.ORCID https://orcid.org/0000-0001-9231-9796
Kazuhiro HoriiDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.ORCID https://orcid.org/0009-0005-7799-2559
Iori Niitsu MorimotoDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.ORCID https://orcid.org/0009-0009-0855-9013
Yuka MoritaDepartment of Otolaryngology-Head and Neck Surgery, University of Toyama, Sugitani, Toyama, Japan.
Fumiaki NinDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan.ORCID https://orcid.org/0000-0002-0408-7540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin is widely used in cancer treatment but can cause hearing loss, predominantly at high frequencies. Auditory responses to bone-conducted ultrasonic stimulation have been proposed as a potential indicator of cochlear function, but it remains unclear how such responses are affected by cochlear damage. In this study, we measured auditory brainstem response (ABR) thresholds within and beyond the conventional hearing range in a mouse model of cisplatin-induced hearing loss. Of 32 mice initially examined, 9 were excluded at baseline because of pre-existing high-frequency hearing impairment. The remaining animals received either saline or cisplatin, and post-treatment analysis in the cisplatin group was based on 16 surviving mice. Cisplatin administration increased ABR thresholds within the conventional hearing range. In contrast, threshold shifts evoked by bone-conducted ultrasonic stimulation were often smaller. Paired comparison of mean threshold shifts showed that changes evoked by bone-conducted ultrasonic stimulation were significantly smaller than those within the conventional hearing range. These findings show that ABR threshold shifts evoked by bone-conducted ultrasonic stimulation do not necessarily parallel those within the conventional hearing range in cisplatin-treated mice.

Indexed as

Antineoplastic AgentsAuditory ThresholdBone ConductionCisplatinEvoked Potentials, Auditory, Brain StemHearing LossAcoustic StimulationAnimalsAuditory AcuityDisease Models, AnimalMaleMiceAntineoplastic AgentsCisplatin

Identifiers

PMID42461856
PMCPMC13374921

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.