ArticleProceedings of the National Academy of Sciences of the United States of America2026
Virtual ultrasound machine operating in a GHz to MHz frequency range for particle-based biomedical simulations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Ultrasound-matter interactions underpin numerous biomedical and soft-matter applications, yet simulating these phenomena is challenging due to the large separation of viscous and sonic time scales. Continuum methods capture large-scale wave propagation but cannot resolve microscale interactions, while particle-based approaches offer molecular resolution but struggle with efficiency and stability at larger scales. We introduce a particle-based virtual ultrasound machine that uses a smoothed dissipative particle dynamics variant with an implicit pressure solver and a negative-pressure stabilization scheme, required to mimic acoustic propagation across medically relevant MHz-GHz frequencies. We demonstrate its capabilities by modeling the acoustophoresis of encapsulated microbubbles, a key mechanism in ultrasound-mediated drug delivery. Beyond this application, the approach establishes a generalizable platform for simulating wave-matter interactions in soft and biological materials, opening promising directions for computational studies of acoustics-driven phenomena in science and engineering.
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