Evidence map›Paper›PMID 42461584›Full record

ArticleObesity (Silver Spring, Md.)2026

ASK1-Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice.

Anne Goergen, Tenagne D Challa, Carlos Villaroel-Vicente, Marcela Borsigova, Pim P van Krieken, Christian Wolfrum, Matthias Blüher, Stephan Wueest, Daniel Konrad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne GoergenDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.
Tenagne D ChallaDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.
Carlos Villaroel-VicenteDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.
Marcela BorsigovaDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.
Pim P van KriekenDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.
Christian WolfrumInstitute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Matthias BlüherMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Stephan WueestDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-0176-8906
Daniel KonradDivision of Pediatric Endocrinology and Diabetology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-9067-4356

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_179344Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_215451Uniscientia Foundation 208-2023
6 · The paper itself

Abstract

objectiveFibroblast growth factor 21 (FGF21) is a stress-induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.

methodsGlucose and energy metabolism were assessed in liver-specific ASK1 overexpressing (ASK1

resultsHFD-fed ASK1

conclusionsWe describe a novel role of hepatic ASK1 in the synthesis of FGF21. Hence, increasing hepatic ASK1 expression might be a novel strategy to combat obesity-associated metabolic complications.

Indexed as

Fibroblast Growth FactorsLiverMAP Kinase Kinase Kinase 5ObesityActivating Transcription Factor 4AnimalsDiet, High-FatEnergy MetabolismGlucoseHumansMaleMiceMice, Inbred C57BLActivating Transcription Factor 4Atf4 protein, mousefibroblast growth factor 21Fibroblast Growth FactorsGlucoseMAP3K5 protein, humanMap3k5 protein, mouseMAP Kinase Kinase Kinase 5adipose tissuebody weighthigh fat dietinsulin resistanceliver

Identifiers

PMID42461584
PMCPMC13422662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.