Evidence map›Paper›PMID 42461582›Full record

ArticleDigestive diseases and sciences2026

Incidence of Metachronous Gastric Cancer After Endoscopic Submucosal Dissection in Helicobacter pylori-uninfected Early Gastric Cancer.

Yusuke Kawai, Junnosuke Hayasaka, Yorinari Ochiai, Junji Tanaka, Minoru Oda, Hiroshi Yamato, Yugo Suzuki, Yutaka Mitsunaga, Hiroyuki Odagiri, Akira Matsui and 1 more

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Yusuke KawaiDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Junnosuke HayasakaDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan. bandwagondane@gmail.com.
Yorinari OchiaiDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Junji TanakaDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Minoru OdaDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Hiroshi YamatoDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Yugo SuzukiDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Yutaka MitsunagaDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Hiroyuki OdagiriDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Akira MatsuiDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.
Shu HoteyaDepartment of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo, 105-8470, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHelicobacter pylori (H. pylori)-associated gastric cancer can progress to metachronous gastric cancer even after eradication; however, the incidence of metachronous gastric cancer in H. pylori-uninfected cases remains unclear. We aimed to investigate the incidence of metachronous gastric cancer after endoscopic submucosal dissection (ESD) in H. pylori-uninfected patients.

methodsThis single-center retrospective cohort study included 850 consecutive patients with gastric cancer (850 lesions) who underwent ESD between January 2010 and December 2021. The primary endpoint was the first metachronous gastric cancer detected more than 1 year after ESD. The secondary endpoint was synchronous gastric cancer detected within 1 year of ESD.

resultsIn total, 38 and 812 of the patients were H. pylori-uninfected and H. pylori-infected, respectively. Synchronous gastric cancer was less frequent in the H. pylori-uninfected group (0% vs. 7.0%), although the difference was not significant (p = 0.103). Metachronous gastric cancer was significantly less frequent in the H. pylori-uninfected group (0% vs. 16.9%, p = 0.002), and the cumulative incidence was significantly lower (p = 0.011). In exploratory multivariable Firth's penalized Cox regression analyses, H. pylori-uninfected status remained associated with a lower estimated risk of metachronous gastric cancer, although the association did not reach statistical significance.

conclusionsThe incidence of metachronous gastric cancer after ESD for early gastric cancer is lower in H. pylori-uninfected patients than in H. pylori-infected patients. Although these findings should be interpreted as exploratory, they suggest that the optimal post-ESD surveillance strategy for H. pylori-uninfected patients warrants further investigation.

Indexed as

Endoscopic Mucosal ResectionHelicobacter InfectionsHelicobacter pyloriNeoplasms, Second PrimaryStomach NeoplasmsAgedFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesEndoscopic submucosal dissectionGastric cancerHelicobacter pyloriPatients

Identifiers

PMID42461582

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