Evidence map›Paper›PMID 42461577›Full record

ArticleJournal of endocrinological investigation2026

Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses.

Noriyoshi Takano, Yasufumi Seki, Yuko Inoue, Kiyotaka Hirata, Daisuke Watanabe, Satoshi Morimoto, Yuichi Oda, Kosaku Amano, Takakazu Kawamata, Atsuhiro Ichihara

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Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noriyoshi TakanoDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.ORCID http://orcid.org/0009-0002-6476-0183
Yasufumi SekiDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan. seki.yasufumi@twmu.ac.jp.ORCID http://orcid.org/0000-0002-1950-7704
Yuko InoueDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Kiyotaka HirataDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Daisuke WatanabeDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6526-829X
Satoshi MorimotoDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2292-2319
Yuichi OdaDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.ORCID http://orcid.org/0009-0006-3294-6812
Kosaku AmanoDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5589-4852
Takakazu KawamataDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6076-7065
Atsuhiro IchiharaDivision of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3872-9767

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFat accumulation leads to obesity, which increases the risk of cardiovascular diseases. Recent studies have shown that adipose (pro)renin receptor ([P]RR) may play a role in fat accumulation, and we previously reported increased adipose (P)RR expression in growth hormone (GH) deficiency in mice; however, the association between human adipose (P)RR expression and GH deficiency remains unclear.

methodsIn this prospective study, abdominal subcutaneous adipose tissue was collected during pituitary surgery in patients with non-functioning hypothalamic-pituitary masses, and the associations between adipose (P)RR mRNA expression, determined using reverse transcription-polymerase chain reaction, and GH deficiency and other clinical parameters were investigated.

resultsFifteen patients (5 craniopharyngioma, 4 non-functioning pituitary neuroendocrine tumor, 4 Rathke's cleft cyst, and 2 other diseases) (mean age, 53 ± 17 years; male sex, 3 [20%]; and mean body mass index [BMI], 24.8 ± 4.3 kg/m

conclusionAdipose (P)RR expression may be increased in GH deficiency, suggesting the possible role of adipose (P)RR in fat accumulation in GH deficiency.

Indexed as

ATP6AP2Growth hormoneInsulin-like growth factor-1ObesityPituitary

Identifiers

PMID42461577

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