Evidence map›Paper›PMID 42461487›Full record

SynthesisJournal of gastrointestinal cancer2026

Routine Lymph Node Dissection in the Surgical Treatment of Primary Liver Tumors: a Systematic Review and Meta-Analysis.

Britte L Buisman, Lucas Goense, Frederik J H Hoogwater, Maarten W Nijkamp, Inne H M Borel Rinkes, Jeroen Hagendoorn, Jelmer E Oor

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Britte L BuismanDepartment of Surgical Oncology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, the Netherlands.
Lucas GoenseDepartment of Surgical Oncology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, the Netherlands.
Frederik J H HoogwaterDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Centre Groningen, Groningen, the Netherlands.
Maarten W NijkampDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Centre Groningen, Groningen, the Netherlands.
Inne H M Borel RinkesDepartment of Surgical Oncology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, the Netherlands.
Jeroen HagendoornDepartment of Surgical Oncology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, the Netherlands.
Jelmer E OorDepartment of Surgical Oncology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, the Netherlands. j.e.oor@umcutrecht.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe incidence of LNM and survival outcomes following routine lymph node dissection (LND) in patients undergoing resection of hepatocellular carcinoma (HCC), intrahepatic- (ICC) and perihilar cholangiocarcinoma (PCC) has not been well-defined. This systematic review and meta-analysis analyzes the incidence of LNM and survival outcomes following routine LND independently of pre-or intraoperative suspicion of LNM following resection of HCC, ICC, and PCC.

methodsThe PubMed database was searched from database inception until March, 2025. Random-effects meta-analysis of the incidence of LNM and hazard ratios (HRs) of overall survival (OS) were conducted for each malignancy.

resultsForty studies were included. Routine LND was performed in 5 872 patients. The pooled incidence of LNM following routine LND was 5% among 601 HCC patients, 37% among 2 565 ICC patients, and 39% among 2 706 PCC patients. Presence of LNM was associated with worse OS in ICC (HR: 2.46, 95% CI 1.66-3.65) and PCC (HR: 2.01, 95% CI 1.74-2.33) patients.

conclusionRoutine LND should be performed during resection of ICC and PCC due to the high incidence of LNM and improved survival outcomes, but not during resection of HCC. The presence of LNM gives inferior survival outcomes in ICC and PCC patients.

Indexed as

Bile Duct NeoplasmsCarcinoma, HepatocellularKlatskin TumorLiver NeoplasmsLymph Node ExcisionHepatectomyHumansLymphatic MetastasisLymph NodesHepatocellular CarcinomaHilar CholangiocarcinomaIntrahepatic CholangiocarcinomaLymphadenectomyLymph node metastasis

Identifiers

PMID42461487
PMCPMC13375768

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.