Evidence map›Paper›PMID 42461485›Full record

ArticleAIDS and behavior2026

Resilience and Its Determinants Among Adolescents and Young Adults with Perinatally Acquired HIV Enrolled in a Peer-Led Mentorship Program in India.

Anita Shet, Michael Raj, Siddha Sannigrahi, Babu Seenappa, Lakshmikanth Reddy, Ashley Sharma, Akshay G Narayanan, S K Satish Kumar, Lakshmi Ganapathi

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Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Anita Shet *Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. ashet1@jhu.edu.ORCID http://orcid.org/0000-0002-7204-8164
Michael Raj *RISHI Foundation, Bengaluru, India.
Siddha SannigrahiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Babu SeenappaRISHI Foundation, Bengaluru, India.
Lakshmikanth ReddyRISHI Foundation, Bengaluru, India.
Ashley SharmaDivision of Pediatric Global Health, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Akshay G NarayananDivision of Pediatric Global Health, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
S K Satish KumarY.R. Gaitonde Center for AIDS Research and Education, Chennai, India.
Lakshmi GanapathiDivision of Pediatric Global Health, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Funding

Yuva Sath (Youth Together): A peer-led intervention to support substance use treatment engagement and HIV prevention among young people who inject drugsK23DA057151 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI Lakshmi Ganapathi · 2023 to 2026
$777k
Johns Hopkins Bloomberg School of Public Health Johns Hopkins Bloomberg School of Public HealthJohns Hopkins University Global Health Field Placement AwardNIDA NIH HHS K23DA057151
6 · The paper itself

Abstract

Adolescents and young adults with perinatally acquired HIV (APHIV) face intersecting challenges that compromise resilience, an important determinant of treatment engagement and health outcomes. Evidence on peer-led interventions to strengthen resilience among APHIV in South Asia remains limited. We evaluated resilience and its correlates among participants in the I'mPossible Fellowship, a peer-led mentorship program in India. We conducted a cross-sectional evaluation of 216 APHIV who completed the 24-month fellowship in southern India in 2024. Trained youth investigators administered surveys assessing sociodemographic, educational, and clinical characteristics. Resilience was measured using the Child and Youth Resilience Measure-Revised (CYRM-R). Low resilience was defined as CYRM-R score ≤ 33rd percentile. Multivariable logistic regression identified independent correlates of low resilience. Participants had a mean age of 18.7y (range 9-24). For 50%, both parents were deceased, and 43% lived in childcare institutions. Median resilience scores were high (74, IQR 69-78), and 91% were virally suppressed. Independent correlates of low resilience were loss of both parents (aOR 4.35, 95% CI 2.09-9.06), school discontinuation (aOR 2.43, 95% CI 1.10-5.34), and communication barriers at HIV clinics (aOR 5.83, 95% CI 2.69-12.64). These findings were consistent across sensitivity analyses using alternative CYRM-R thresholds. At the stringent resilience threshold of ≤ 15th percentile, unsuppressed viral load emerged an additional significant correlate of low resilience. We conclude that APHIV participating in this peer-led mentorship program demonstrated high resilience and viral suppression. Results highlighted modifiable structural and psychosocial vulnerabilities that could inform targeted interventions to improve outcomes among those facing the greatest adversity.

Indexed as

Adolescents and young adultsCommunity-based participatory researchPeer mentorshipPerinatally-acquired HIVResilience

Identifiers

PMID42461485

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