Evidence map›Paper›PMID 42461452›Full record

ReviewMedical oncology (Northwood, London, England)2026

The Oncogenic LncRNA-PVT1 in colorectal cancer: mechanisms of ceRNA-mediated progression and clinical implications.

Fatemeh Sousanabadi Farahani, Sara Mehrmohammadi, Zahra Ghanei, Zahra Sadeghloo, Amir Sadeghi, Nayeralsadat Fatemi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fatemeh Sousanabadi Farahani *Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sara Mehrmohammadi *Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra GhaneiDepartment of Biotechnology, Faculty of Biological Science, Alzahra University, Tehran, Iran.
Zahra SadeghlooBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amir SadeghiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nayeralsadat FatemiBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. n.fatemi@sbmu.ac.ir.ORCID http://orcid.org/0000-0001-7906-2260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with both genetic and epigenetic factors contributing to its initiation and progression. Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of tumorigenesis. Among these, plasmacytoma variant translocation 1 (PVT1) has attracted increasing attention due to its oncogenic functions. PVT1 primarily acts as a competing endogenous RNA (ceRNA), sequestering tumor-suppressive microRNAs to promote cancer progression. Additionally, polymorphisms within the PVT1 locus have been associated with CRC susceptibility and treatment response. This review summarizes the molecular mechanisms through which PVT1 contributes to CRC pathogenesis and highlights its clinical potential as a diagnostic and prognostic biomarker.

Indexed as

Colorectal NeoplasmsRNA, Long NoncodingBiomarkers, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansMicroRNAsRNA, Competitive EndogenousBiomarkers, TumorMicroRNAsPVT1 long-non-coding RNA, humanRNA, Competitive EndogenousRNA, Long NoncodingceRNAColorectal cancerlncRNAsPVT1

Identifiers

PMID42461452

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.