ArticleMarine biotechnology (New York, N.Y.)2026
Limpet-Derived Ferritin Promotes Iron Teeth Mineralization Through Binding Fe
Article in Marine biotechnology (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Limpets, marine mollusks that feed on algae by scraping rocks, have evolved teeth renowned as among the strongest biological materials known. These teeth are iron-based biocomposites, primarily consisting of goethite nanorods embedded within a silica-rich matrix. A central mystery has been how limpets produce goethite-a mineral that typically requires extreme synthetic conditions-under ambient physiological settings. Here, we combined transcriptomics and functional assays to investigate the teeth of the limpet Cellana toreuma. RNA-seq in compartmented regions of teeth found differential gene expression for teeth formation involving intensive chitin metabolism and redox reaction. Through RNA interference, we demonstrated that a specific limpet-derived ferritin is essential for tooth iron accumulation and mineralization in vivo. We further identified and characterized this ferritin, showing its ability to bind Fe
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