ArticleActa parasitologica2026
Acaricidal Activity and Transcriptional Modulation Induced by Randia aculeata Seed Extract in Rhipicephalus microplus.
Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe cattle tick Rhipicephalus microplus is a major ectoparasite affecting livestock worldwide, and its increasing resistance to synthetic acaricides has intensified the search for plant-derived alternatives. Although the hydroalcoholic seed extract of Randia aculeata has demonstrated acaricidal activity, its molecular effects in ticks remain poorly understood. This study evaluated the acaricidal activity of the extract and the underlying molecular mechanism against R. microplus larvae.
methodsThe acaricidal activity was evaluated using the larval packet test, and the underlying mechanism was investigated through transcriptional analysis of acetylcholinesterase 2 (AChE2) and glutathione S-transferase (GST) genes. LC
resultsThe extract demonstrated acaricidal activity, with 50% and 90% lethal concentration values of 2.84 mg/mL and 5.67 mg/mL, respectively. Exposure to the LC
conclusionsThe hydroalcoholic extract of R. aculeata exhibited acaricidal activity and was associated with transcriptional suppression of genes involved in neurotransmission and detoxification. These findings suggest that the extract may affect pathways related to cholinergic regulation and xenobiotic response. However, because the susceptibility status of the evaluated field-derived population was not determined, the observed molecular responses should be interpreted with caution. Further studies using well-characterized susceptible and resistant tick populations are needed to clarify the mechanisms underlying the biological activity of the extract.
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