Evidence map›Paper›PMID 42461424›Full record

ArticleActa neurochirurgica2026

Addressing connectomic constraints in early practice of awake-guided neurosurgery: a four-year prospective case-matched analysis.

Sam Ng, Andrea Otamendi-Lopez, Basile Martin, Kevin Chalard, Vivien Szabo, Sylvie Moritz-Gasser, Guillaume Herbet, Hugues Duffau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sam NgDepartment of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34090, Montpellier, France. s-ng@chu-montpellier.fr.ORCID https://orcid.org/0000-0001-7232-319X
Andrea Otamendi-LopezDepartment of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34090, Montpellier, France.
Basile MartinDepartment of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34090, Montpellier, France.
Kevin ChalardInstitute of Functional Genomics, U1191 Laboratory, University of Montpellier, INSERM, CNRS, National Institute for Health and Medical Research (INSERM), Montpellier, France.
Vivien SzaboInstitute of Functional Genomics, U1191 Laboratory, University of Montpellier, INSERM, CNRS, National Institute for Health and Medical Research (INSERM), Montpellier, France.
Sylvie Moritz-GasserDepartment of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34090, Montpellier, France.
Guillaume HerbetDepartment of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34090, Montpellier, France.
Hugues DuffauDepartment of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34090, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAwake functional-guided resection (AFGR) is the gold-standard approach in glioma surgery. The learning curve associated with mastering white matter tracts (WMT) identification using direct electrostimulation (DES) mapping remains poorly characterized. The goal of this study was to compare subcortical DES mapping performance between early-career and expert neurosurgeons.

methodsIn this prospective, monocentric, case-matched study, patients undergoing AFGR (2022-2025) were operated on either by an early-career neurosurgeon during the first four years of independent practice (cohort

resultsOverall, 352 AFGR procedures were analyzed, including 101 in cohort

conclusionBenchmarking early-career practice of AFGR against expert practice reveals selective, tract- and functional system-specific differences in DES mapping strategies, with minimal impact on EOR and similar functional outcomes. These findings suggest that AFGR is reliably implementable during early independent practice and support a dynamic connectomic constraint framework to guide training.

Indexed as

Brain NeoplasmsConnectomeGliomaNeurosurgeonsNeurosurgical ProceduresWhite MatterAdultBrain MappingCase-Control StudiesElectric StimulationFemaleHumansMaleMiddle AgedProspective StudiesWakefulnessAwake surgeryDirect electrostimulationFunctional mappingGliomaNeurosurgical training

Identifiers

PMID42461424
PMCPMC13658417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.