Evidence map›Paper›PMID 42461364›Full record

ReviewDiabetes therapy : research, treatment and education of diabetes and related disorders2026

Pen Needle Reuse in People with Diabetes Who Inject Insulin: A Narrative Review.

Diana Isaacs, Davida Kruger, Susan Cornell, Sanjay Kalra, Sandro Gentile

Abstract readReview
In one paragraph

Review in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Diana IsaacsCleveland Clinic, Cleveland, OH, USA.
Davida KrugerHenry Ford Health, Detroit, MI, USA.
Susan CornellBolingbrook Christian Health Clinic, Bolingbrook, IL, USA.
Sanjay KalraBharti Hospital, Karnal, Haryana, India.
Sandro GentileCampania University, Naples, Italy. s.gentile1949@gmail.com.ORCID http://orcid.org/0000-0002-9059-6121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGlobal rates of insulin pen needle (PN) reuse in people with diabetes (PWD) vary across regions. However, it is estimated that more than 50% of PWD will reuse their PNs at some point over the course of their disease management. This highlights the need for better education to avoid this practice, which can lead to complications such as lipohypertrophy, pain, and poor glycemic management. This review aims to educate healthcare professionals (HCPs) on the issues surrounding PN reuse by PWD; discuss the scientific and clinical rationale for and against PN reuse; provide guidance on best practice for PN use by PWD who use insulin when reuse continues or is unavoidable; and provide actionable insights for clinical education and person-centered support interventions.

methodsTo compile the data on PN reuse, a PubMed search was conducted in November 2025, with "diabetes", "insulin", and "needle reuse" as the search terms. Over 100 articles were found and assessed for inclusion based on scientific vigor, leaving approximately 40 articles for inclusion.

resultsThe main reasons for PN reuse were stated to be convenience and cost in many regions around the world.

conclusionsThe findings of this review suggest that reducing PN reuse rates requires continued, ongoing education about injection technique and potential complications of PN reuse. Ideally, this education should be provided by HCPs and diabetes educators, as they are the most trusted source of information for PWD. It is vital to determine the reasons for reuse without judgment and discuss suitable solutions to mitigate the problem.

Indexed as

Injection technique questionnaireInsulin injectionInsulin injection techniqueInsulin injection technique educationPen needlePen needle reuse

Identifiers

PMID42461364
PMCPMC13546391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.