Evidence map›Paper›PMID 42461342›Full record

ArticleJournal of physiology and biochemistry2026

Aryl hydrocarbon receptor deficiency leads to sex- and age-dependent colonic dysmotility in mice.

Alicia Valls, David Verdú, Sol Guerra-Ojeda, Teresa San-Miguel, Andrea Suarez, Javier Pereda, Verónica Gómez-Jiménez, José Viña, Maria D Mauricio, Eva Serna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alicia Valls *Department of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
David Verdú *Department of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Sol Guerra-OjedaDepartment of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Teresa San-MiguelDepartment of Pathology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Andrea SuarezDepartment of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Javier PeredaDepartment of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Verónica Gómez-JiménezDepartment of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
José ViñaDepartment of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Maria D Mauricio *Department of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain.
Eva Serna *Department of Physiology, Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, 46010, Spain. eva.serna@uv.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in xenobiotic sensing and multiple physiological functions, including intestinal homeostasis. Aging is associated with reduced colonic motility and constipation, but the contribution of AhR to intestinal motor function across sex and age remains incompletely defined. We performed a phenotypic characterization of AhR-deficient (AhR

Indexed as

AgingBasic Helix-Loop-Helix ProteinsColonConstipationGastrointestinal MotilityReceptors, Aryl HydrocarbonAcetylcholineAge FactorsAnimalsAquaporin 1AquaporinsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutAcetylcholineAhr protein, mouseAqp1 protein, mouseAquaporin 1aquaporin 8AquaporinsBasic Helix-Loop-Helix ProteinsNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type INitric Oxide Synthase Type IINos1 protein, mouseNos2 protein, mouseReceptors, Aryl HydrocarbonUbiquitin ThiolesteraseAgingAryl hydrocarbon receptorColonEnteric nervous systemIntestinal motilitySex differences

Identifiers

PMID42461342
PMCPMC13375827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.