ReviewArchives of microbiology2026
Aspergillus flavus-peanut (Arachis hypogaea L.) interactions: pathogenesis, diagnosis, and sustainable management of yellow mold disease.
Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus flavus is a globally significant threat to peanut (Arachis hypogaea L.) production, causing yellow mold disease and contaminating crops with carcinogenic aflatoxins. This review synthesizes current knowledge on the origins, pathogenesis, diagnosis, and sustainable management of this disease, with a specific focus on pre-harvest interventions. The disease cycle originates from soil-borne inoculum and spreads via wind and insects. As a saprophytic opportunist, A. flavus deploys hydrolytic enzymes, with host lipids governing sporulation and aflatoxin biosynthesis. Pathogenicity is orchestrated by an intricate signalling network: GPCRs sense host oxylipins, activating cAMP/PKA and three MAPK cascades (Fus3, HOG, CWI), while the TOR pathway functions as an independent nutrient sensor; these converge on the velvet complex (VeA, VelB, LaeA) to regulate development and virulence. Diagnosis integrates visual scales, culture, chemical (TLC, HPLC-MS/MS), immunological (ELISA), and molecular tools (PCR, qPCR, LAMP). Management strategies have advanced through breeding partially resistant cultivars (leveraging defense-related genes, microRNAs, and CRISPR-based tools) and biological control using non-aflatoxigenic A. flavus strains, beneficial bacteria, microbial cell-free supernatants, and plant metabolites. However, we critically evaluate concerns that non-aflatoxigenic biocontrol strains may retain plant-pathogenic potential independent of aflatoxin production. Because complete genetic resistance remains elusive, we advocate integrated disease management combining host resistance, biocontrol, cultural practices, and climate-adaptive surveillance. Future priorities include elucidating the ecological role of sexual recombination, validating field-deployable diagnostics, implementing digital phenotyping, and developing predictive models that incorporate climate change scenarios to safeguard peanut production and global food safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.