Evidence map›Paper›PMID 42461258›Full record

Observational studyCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026

Drug-Coated Balloon-Based Strategy for De Novo Coronary Artery Disease Across Complex and High-Risk Indicated Percutaneous Coronary Intervention Risk Categories: A Multicenter Registry Study.

Dong Oh Kang, Sunwon Kim, Ae-Young Her, Eun-Seok Shin

2 registry-linked trialsAbstract readMulticenter StudyComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04619277 recruitingnot on this map

Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion

Typeobservational_patient_registrySponsorUlsan Medical CenterRan2011 to 2030Enrolled10,000ConditionsDrug-coated BalloonArmsdrug-coated balloon
NCT04734028 completednot on this map

Platelet Function and genoType-Related Long-term progGosis in DES-treated Patients : A Consortium From Multi-centered Registries

TypeobservationalSponsorGyeongsang National University HospitalRan2003 to 2020Enrolled13,160ConditionsCoronary Artery Disease, Clopidogrel, Poor Metabolism of, Platelet Dysfunction, Stent ThrombosisArmsClopidogrel Tablets
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Drug-Coated Balloon-Based Strategy for De Novo Coronary Artery Disease Across Complex and High-Risk Indicated Percutaneous Coronary Intervention Risk Categories: A Multicenter Registry Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dong Oh KangCardiovascular Center, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
Sunwon KimCardiovascular Center, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea.
Ae-Young HerDivision of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, South Korea.
Eun-Seok ShinDepartment of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.ORCID https://orcid.org/0000-0002-9169-6968

Funding

Korean government 2021-NR063386Korean government RS-2023-00210960Korea University K1923481Korea University K2022971Korea University K2111151Korea University K2211921Korea University K2225581Korea University K2512341
6 · The paper itself

Abstract

backgroundEvidence regarding the risk-stratified effectiveness of drug-coated balloon (DCB)-based PCI for de novo coronary artery disease (CAD) remains limited, particularly in patients undergoing complex and high-risk indicated percutaneous coronary intervention (CHIP PCI).

aimsTo compare the efficacy and safety of DCB-based PCI versus DES-only PCI for de novo CAD across CHIP risk categories.

methodsPatients treated with DCB alone or with a hybrid DCB/drug-eluting stent (DES) strategy between 2010 and 2023 were retrospectively analyzed (DCB-based group). The comparator group included patients treated exclusively with second-generation DES from a Korean multicenter registry. The primary endpoint was the 2-year incidence of major adverse cardiovascular events (MACE): cardiac death, myocardial infarction, target vessel revascularization (TVR), target lesion thrombosis, and major bleeding.

resultsTotal 2022 propensity score-matched pairs were stratified by CHIP score into low (0-2; 1660 pairs), intermediate (3-4; 304 pairs), and high (≥ 5; 91 pairs) risk groups. DCB-only treatment accounted for 70.8% of the DCB-based group, with hybrid approaches more frequent in higher-risk patients. Two-year MACE rates increased with CHIP risk in both groups, but remained consistently lower in the DCB-based group: 5.3%, 6.3%, and 20.0% versus 10.9%, 16.9%, and 31.2% for DES-only PCI (log-rank p < 0.001). DCB-based PCI was associated with lower MACE risk across all CHIP categories (all p < 0.05), with no significant interaction (p-interaction = 0.819). TVR reduction was significant in the low-to-intermediate risk (p-interaction = 0.056), and major bleeding declined with increasing CHIP risk, most notably in the high-risk group (p-interaction = 0.044).

conclusionsDCB-based PCI was associated with significantly lower 2-year MACE rates across all CHIP risk categories and may offer a potential alternative to DES-only strategies in selective patients. Clinical trial registration number REAL-DCB registry (NCT04619277), PTRG-DES registry (NCT04734028).

Indexed as

Angioplasty, Balloon, CoronaryCardiac CathetersCardiovascular AgentsCoated Materials, BiocompatibleCoronary Artery DiseaseAgedDrug-Eluting StentsFemaleHumansMaleMiddle AgedRegistriesRepublic of KoreaRetrospective StudiesRisk AssessmentRisk FactorsCardiovascular AgentsCoated Materials, Biocompatiblecomplex and high‐risk indicated procedurecoronary artery diseasedrug‐coated balloonpaclitaxel‐coated balloonpercutaneous coronary intervention

Identifiers

PMID42461258
PMCPMC13667322

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.