Evidence map›Paper›PMID 42461164›Full record

ArticleClinical physiology and functional imaging2026

Myocardial perfusion reserve is low in heart transplant patients and is related to exercise capacity.

Kristian Dimovski, Grunde Gjesdal, Katarina Steding-Ehrenborg, Robert Jablonowski, Hui Xue, Peter Kellman, Oscar Braun, Håkan Arheden, Henrik Engblom

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Article in Clinical physiology and functional imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kristian DimovskiDepartment of Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.ORCID https://orcid.org/0009-0009-3678-4074
Grunde GjesdalCardiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Katarina Steding-EhrenborgDepartment of Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Robert JablonowskiDepartment of Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Hui XueNational Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA.
Peter KellmanDepartment of Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Oscar BraunCardiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Håkan ArhedenDepartment of Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Henrik EngblomDepartment of Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.

Funding

Hjärt-Lungfonden HLF 20180356Medicinska Fakulteten, Lunds UniversitetRegion Skåne ALF 444011
6 · The paper itself

Abstract

aimsHeart transplant (HTx) patients are known to be at risk of coronary microvascular dysfunction as well as having decreased exercise capacity. The aim of this study was to investigate if microvascular function in HTx patients differs from healthy controls and is related to objective measures of exercise capacity. METHODS AND

resultsTwenty-nine HTx patients (51 ± 15 years, 34% women) and 26 healthy controls (57 ± 10 years, 38% women) underwent CMR. Quantitative myocardial perfusion maps were acquired using single-bolus (0.05 mmol/kg), dual-sequence perfusion mapping at adenosine stress and at rest. In addition, all HTx patients performed a maximal cardiopulmonary exercise test with gas-exchange analysis for objective assessment of exercise capacity. Heart transplant patients had lower stress myocardial perfusion (2.9 ± 0.8 vs 3.4 ± 0.8, p = 0.03) and lower myocardial perfusion reserve (MPR) (2.7 ± 0.7 vs 3.8 ± 1.2, p < 0.001) compared to healthy controls. Furthermore, MPR in HTx patients was correlated with maximal workload (R

conclusionMicrovascular function as assessed by quantitative CMR perfusion mapping is lower in HTx patients than in healthy controls and is partly related to objective measures of exercise capacity.

Indexed as

Coronary CirculationExercise ToleranceHeart TransplantationMicrocirculationMyocardial Perfusion ImagingAdenosineAdultAgedCase-Control StudiesExercise TestFemaleHumansMaleMiddle AgedOxygen ConsumptionPerfusion Magnetic Resonance ImagingAdenosineVasodilator Agentscardiac transplantCPETmicrovascular dysfunctionmyocardial perfusionquantitative CMR

Identifiers

PMID42461164
PMCPMC13374594

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