Evidence map›Paper›PMID 42461117›Full record

ArticleGut microbes2026

Gut-derived genistein from

Demengjie Le, Mohammad Hassan Heidari, Shunmin Zhu, Yingying Luo, Changzhou Li, Yue Li, Bin Yang, Xuan Wang

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Demengjie LeDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0003-1188-6129
Mohammad Hassan HeidariDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0009-0008-3398-6618
Shunmin ZhuDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0009-0008-8970-7307
Yingying LuoDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0002-4424-2787
Changzhou LiDepartment of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0002-9797-333X
Yue LiDepartment of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0009-0000-0974-6827
Bin YangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0002-7155-6079
Xuan WangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0002-8978-2576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut-skin axis plays a pivotal role in psoriasis pathogenesis, yet the precise metabolic crosstalk by which intestinal commensals regulate cutaneous immunity remains elusive. Here, we identify a functional "microbe-enzyme-metabolite-immune" axis that orchestrates skin homeostasis. Through multi-omics analyses of psoriatic patients and imiquimod-induced murine models, we reveal a significant depletion of the gut commensal

Indexed as

Antigens, CDGenisteinNF-kappa BPsoriasisAnimalsDisease Models, AnimalFemaleGastrointestinal MicrobiomeHumansInflammationMaleMiceMice, Inbred C57BLSignal TransductionSkinAntigens, CDantigens, CD200GenisteinNF-kappa BCD200genisteinGut–skin axisparabacteroides distasonispsoriasis

Identifiers

PMID42461117
PMCPMC13378712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.