ArticleMicrobiology spectrum2026
Whole-genome sequencing analysis of clinical carbapenemase-producing bacteria isolated in Dakar, Senegal.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antimicrobial resistance, particularly to carbapenems, represents a major global public health threat. In Senegal, the increasing prevalence of carbapenem-resistant Gram-negative bacilli compromises the management of severe infections. This study, conducted between October 2022 and March 2024 at the Centre Hospitalier National Universitaire de Fann and the Institut Pasteur de Dakar, investigated 50 carbapenem-resistant bacterial isolates. Species identification was performed using Vitek 2 and MALDI-TOF MS, and antimicrobial susceptibility was assessed by disk diffusion testing. Whole-genome sequencing enabled the detection of resistance genes, plasmid replicons, and clonal lineages through MLST analysis. Among the 50 isolates, 35 (70%) carried at least one carbapenemase gene. The
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