ArticleMicrobiology spectrum2026
Co-receptor usage in distinct phylogenetic clusters of HIV-1 CRF01_AE is associated with differential immune reconstitution after antiretroviral therapy.
Yangyang Liu, Jing Lu, Tao Qiu, Zhiliang Hu, Wei Li, Xiaoshan Li, Guoping Du, Meng Zhao, Hongfei Ma, Pingmin Wei and 2 more
Abstract readMulticenter Study
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Yangyang Liu *Department of Infectious Disease, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.ORCID 0000-0003-4344-4034 Jing Lu *Institute of HIV/AIDS/STI Prevention and Control, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, China.
Tao QiuInstitute of HIV/AIDS/STI Prevention and Control, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, China.
Zhiliang HuDepartment of Infectious Disease, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wei LiDepartment of Quality Management, Children's Hospital of Nanjing Medical University, Nanjing, China.
Xiaoshan LiNanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, China.
Guoping DuSoutheast University Hospital, Southeast University, Nanjing, Jiangsu, China.
Meng ZhaoDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Hongfei MaDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Pingmin WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.ORCID 0000-0002-7456-0209 Dandan YangInstitute of HIV/AIDS/STI Prevention and Control, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, China.ORCID 0009-0000-7466-8044 You GeDepartment of Infectious Disease, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.ORCID 0000-0003-4497-7916 Funding
China Postdoctoral Science Foundation 2022M721682Talent Support Program of Nanjing Second Hospital RCZD25004Youth Program of the National Natural Science Foundation of China 82103896
6 · The paper itselfAbstract
HIV-1 CRF01_AE cluster 4 is the predominant strain among men who have sex with men (MSM) in China and comprises two lineages, clusters 4a and 4b. We aimed to compare immune reconstitution after antiretroviral therapy (ART) between individuals infected with clusters 4a and 4b and to explore virological determinants underlying cluster-specific differences. We conducted a multicenter cohort study in Jiangsu Province, China, enrolling 604 cluster 4-infected patients with sustained viral suppression after 24 weeks of ART. We used generalized additive mixed models to characterize CD4
Indexed as
HIV-1HIV InfectionsImmune ReconstitutionReceptors, HIVAdultAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesChinaCohort StudiesFemaleHomosexuality, MaleHumansMaleMiddle AgedPhylogenyReceptors, CXCR4Receptors, HIVcluster 4co-receptor tropismCRF01_AEHIV-1immune reconstitution
Identifiers
PMID42461040
PMCPMC13436356
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