Evidence map›Paper›PMID 42461022›Full record

ArticlemBio2026

Homocysteine thiolactone from translation proofreading is an endogenous ligand for cell-cell signaling by the receptor SdiA.

Lorenzo Eugenio Leiva, Roberto A Zúñiga, Gregory J Phillips, Michael Ibba

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lorenzo Eugenio LeivaSchmid College of Science and Technology, Chapman University, Orange, California, USA.
Roberto A ZúñigaSchmid College of Science and Technology, Chapman University, Orange, California, USA.
Gregory J PhillipsDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-0048-512X
Michael IbbaSchmid College of Science and Technology, Chapman University, Orange, California, USA.ORCID 0000-0002-5318-1605

Funding

Army Research Office W911NF-20-1-0152
6 · The paper itself

Abstract

Several widespread mechanisms enable cellular communication and coordinate the behavior of bacterial populations. The modules responsible for cellular communication are often found in matching pairs: an enzyme that synthesizes a signal molecule and a specific receptor that decodes it. A notable exception is

Indexed as

Escherichia coliEscherichia coli ProteinsHomocysteineSignal TransductionGene Expression Regulation, BacterialLigandsProtein BiosynthesisEscherichia coli ProteinsHomocysteinehomocysteine thiolactoneLigandsmethionineproofreadingsynthetasetranslationtRNA

Identifiers

PMID42461022
PMCPMC13463772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.