ArticleJACC. Case reports2026
Myocardial Inflammation Reveals a Genetic Desmosomal Cardiomyopathy in an Athlete.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
backgroundMyocarditis frequently overlaps with phases of myocardial inflammation in inherited cardiomyopathies. CASE SUMMARY: A 32-year-old female athlete was referred because of bradycardia, troponin elevation, and high burden of premature ventricular contractions. Cardiac magnetic resonance imaging demonstrated features of both potential myocardial inflammation and arrhythmogenic right ventricular cardiomyopathy (ARVC). Despite clinical stability, troponin I levels rose to a peak level of 304,065 ng/L. Endomyocardial biopsy showed evidence of acute lymphocytic myocarditis, and immunosuppressive therapy was initiated. Genetic testing revealed a likely pathogenic variant in the PKP2 gene, which encodes plakophilin 2. A diagnosis of ARVC was made. DISCUSSION: This case highlights the overlap between apparent myocarditis in an athlete and "hot-phase" ARVC. TAKE-HOME MESSAGE: Genetic testing may have an important role in athletes presenting with myocarditis, because high-intensity exercise may trigger rapid disease progression and increases the risk for ventricular arrhythmias in patients with inherited cardiomyopathies, especially in ARVC.
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