ArticleJACC. Case reports2026
Coronary Artery Aneurysms and Dilation in Children With RASopathies.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRASopathies are disorders caused by variants in a gene in the RAS-mitogen-activated protein kinase (RAS-MAPK) pathway that have an association with cardiovascular anomalies, most commonly pulmonary stenosis and hypertrophic cardiomyopathy. There are some reported cases of coronary artery aneurysms (CAAs) in patients with RASopathies, but there is limited understanding of CAAs in this population, particularly in younger patients and in those with varying genotypes. CASE SUMMARY: We describe 3 pediatric cases of patients with RASopathy developing CAA or ectasia: a 3-year-old with CBL-related RASopathy with giant CAAs, one of which required surgical intervention with a coronary artery bypass graft; an 8-year-old with PTPN11-related Noonan syndrome with giant CAAs; and an 11-year-old with a clinical diagnosis of Noonan syndrome with coronary ectasia. DISCUSSION: CAAs may be related to underlying RASopathies. Further exploration of the association and pathophysiology of CAAs in RASopathy is needed to guide screening, prevention, and management.
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