Observational studyClinical cardiology2026
Long-Term Follow-up After Percutaneous Coronary Interventions for Chronic Total Occlusions.
Observational study in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chronic Total Occlusions: Current Approaches, Evidence and Outcomes.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPercutaneous coronary interventions (PCI) for chronic total occlusions (CTO) remain challenging procedures with controversial long-term clinical benefits.
methodsWe conducted an observational monocentric study including consecutive patients who underwent PCI for CTO by experienced operators in a French University Hospital between January 2015 and December 2022. All patients had symptoms and/or proven myocardial ischemia. Patients were divided into two groups based on PCI success or failure. The primary endpoint was the occurrence of MACE, defined as the composite of cardiac death, non-fatal myocardial infarction, and target vessel revascularization up to 8 years of follow-up.
resultsOf the 448 patients who underwent a CTO-PCI, 401 (89.5%) had a successful procedure, while 47 (10.5%) experienced a failed intervention. During a mean follow-up of 3.7 years, MACE occurred in 71 patients (15.8%), including 12 patients (25.5%) in the failed group and 59 patients (14.7%) in the successful group (HR 2.68 [1.42; 5.06]; p < 0.01). While both groups had similar baseline clinical risk profiles, the failed CTO-PCI group had a lower overall survival rate (74.5% vs. 88.8%; HR 2.23 [1.17; 4.27]; p = 0.02). The successful CTO-PCI group showed significant improvements in left ventricular ejection fraction (LVEF) (p < 0.01) and NYHA class (p < 0.01). The J-CTO score was the only predictor of procedural failure (1.96 [1.44; 2.67]; p < 0.01).
conclusionsFailed CTO-PCI was associated with increased incidence of MACE. LVEF and NYHA class was improved in successful CTO-PCI, supporting the pursuit of this procedure in selected cases.
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Registered trials
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