ArticleGenetics2026
Developmental patterning of adipose tissue by abd-A and Abd-B homeotic genes in Drosophila melanogaster.
Article in Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Bithorax Complex (BX-C) homeobox proteins specify segmental identities along the anterior-posterior axis during embryogenesis in Drosophila. Differential expression of the BX-C genes abd-A (abdominal-A) and Abd-B (Abdominal-B) distinguishes abdominal from thoracic adipocytes, but the mechanisms underlying this heterogeneity remain unknown. Here, we identify cis-regulatory elements (CREs) and DNA-binding proteins that regulate abdomen-specific expression of abd-A and Abd-B in the larval fat body. Fine-mapping analyses identified a 627-bp CRE within the Abd-B locus and an approximately 6-kb CRE within the abd-A locus that are sufficient to drive region-specific expression. Yeast one-hybrid screening and functional analyses revealed that Lola (Longitudinals lacking), Lolal (Lola like), and Cg (Combgap) repress Abd-B expression, whereas Prg (Piragua) and Svp (Seven up) activate Abd-B transcription. We further show that lola and prg are repressed by Abd-B, whereas lolal and svp are activated by Abd-B, forming a feedback regulatory network. Wnt signaling modulates this network by promoting lola and lolal expression and repressing svp. CUT&RUN (Cleavage Under Targets & Release Using Nuclease) analyses identified dTCF/Pangolin occupancy at the lola, lolal, and svp loci and Abd-B occupancy at the lola and lolal loci, suggesting that a subset of these interactions is direct. Together, these findings define a gene regulatory network that controls Abd-B expression in the larval fat body and provide a molecular mechanism for establishing adipocyte heterogeneity along the anterior-posterior axis.
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