Evidence map›Paper›PMID 42460419›Full record

ArticleMolecular therapy. Advances2026

F/HN-pseudotyped lentiviral vector efficiently transduces non-human primate airways with no evidence of relevant toxicity.

Uta Griesenbach, Gerry McLachlan, Anthony Sinadinos, Cédric Cheminay, Joseph Ashour, Jason Cox, Daniela Schwotzer, Kristin Vyhnal, Aradhana Gupta, Mario Chan and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Uta GriesenbachNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.
Gerry McLachlanUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
Anthony SinadinosNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.
Cédric CheminayBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.
Joseph AshourBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.
Jason CoxLovelace Biomedical, Albuquerque, NM 87108, USA.
Daniela SchwotzerLovelace Biomedical, Albuquerque, NM 87108, USA.
Kristin VyhnalLovelace Biomedical, Albuquerque, NM 87108, USA.
Aradhana GuptaBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.
Mario ChanNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.
Cuixiang MengNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.
Kyriel PineaultNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.
Emily CastellsUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
Rebecca J DeanUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
Mariana A ViegasUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
A Christopher BoydUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
Jane C DaviesNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.
Deborah R GillUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
Stephen C HydeUK Respiratory Gene Therapy Consortium, London SW3 6LR, UK.
Diann BlansetBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.
Eric Wfw AltonNational Heart and Lung Institute, Imperial College London, London SW3 6LR, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed a third-generation lentiviral vector pseudotyped with Sendai virus F and HN envelope proteins (rSIV.F/HN) expressing functional cystic fibrosis transmembrane conductance regulator (CFTR) as a gene therapy for cystic fibrosis (BI 3720931). Here, we assessed transduction efficiency and acute toxicology of the rSIV.F/HN vector expressing an enhanced green fluorescent protein (EGFP) reporter gene in non-human primates (NHPs). Intubated male cynomolgus monkeys received one aerosolized dose of vector (

Indexed as

cystic fibrosisgene therapylentiviral vectorlung gene transfernon-human primatestoxicitytransduction efficiency

Identifiers

PMID42460419
PMCPMC13370165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.