ArticleBiomedical optics express2026
Proto-clinical optoretinography dependence on temporal and spatial resolution.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optoretinography (ORG) enables non-invasive measurement of stimulus-evoked photoreceptor deformation using phase-sensitive optical coherence tomography (OCT). In this study, we evaluated how lateral resolution, acquisition speed, and spatial and inter-trial averaging influence velocity-based phase ORG measured with a raster-scanning spectral-domain OCT platform configured to resemble clinically realistic hardware. Seven healthy eyes were imaged while varying beam diameter (1.6-4.8 mm), B-scan rate (400-800 Hz), and averaging strategies. The characteristic biphasic response, a rapid contraction followed by slower elongation, was consistently observed across all conditions. Increasing NA improved structural cone visibility but did not proportionally enhance averaged ORG metrics, while moderate NA often yielded more stable signals. Higher acquisition speeds sharpened the measured contraction dynamics but reduced the signal-to-noise ratio due to increased phase noise. Both spatial and trial averaging substantially improved SNR. These findings demonstrate that repeatable phase-based ORGs can be achieved without cellular resolution or ultrahigh scan rates, and provide practical guidance for implementing proto-clinical ORG on conventional OCT systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.