ArticleBiomedical optics express2026
Two-photon imaging microscopy of non-stained human epiretinal membranes.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epiretinal membranes (ERMs) are composed of cellular and extracellular matrix elements. They are divided into idiopathic (iERM), of unknown origin, and non-idiopathic (non-iERM), usually associated with proliferative retinopathies and retinal detachment surgery. ERMs have been visualized with complex and highly time-consuming multi-labelling methods, which characterization has been mainly qualitative. Since ERM components may depend on their genesis, two-photon imaging microscopy might be a proper tool to objectively differentiate iERM from non-iERM. In this study we propose the combination of two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) signals to explore and quantify differences between both types of non-stained human ERMs. An index computed from pairs of TPEF-SHG images and an analysis of the collagen-based tissue spatial arrangement have been employed for this purpose.
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