ArticleKidney diseases (Basel, Switzerland)
Lipocalin-2 Emerges as a Core Pathogenic Mediator and Biomarker in Autosomal Dominant Tubulointerstitial Kidney Disease-UMOD via Transcriptomic Profiling.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a group of inherited renal disorders characterized by progressive decline in kidney function, with Methods: Transcriptomic datasets (GSE214491, GSE139585, GSE97093) from ADTKD- Results: In GSE214491 (6 mutant vs 6 wild type mice), 302 DEGs were identified at 4 months, and an additional 117 DEGs were newly characterized at 1 month, when histological disease was minimal. GSE139585 revealed 12 DEGs, and GSE97093 showed 83 and 16 DEGs in male and female cohorts, respectively. Across datasets, Lcn2 was consistently identified as a significant DEG and central hub gene and was already significantly elevated in 1-month-old ADTKD- Conclusion: LCN2 protein emerges as a reproducible biomarker and plausible pathogenic mediator across distinct
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