ArticleCureus2026
FOXR2-Mediated CNS Neuroblastoma in a Pediatric Patient Treated With Multimodal Therapy Including Proton Craniospinal Irradiation: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
FOXR2-activated central nervous system (CNS) neuroblastoma is a rare embryonal tumor characterized by an aggressive nature, frequent leptomeningeal dissemination, and poor prognosis without intensive multimodal therapy. We report a four-year-old girl with multifocal FOXR2-altered CNS neuroblastoma treated with subtotal resection, multi-agent chemotherapy per ACNS0334, autologous stem cell transplant, and proton craniospinal irradiation (CSI) with focal boost. This case highlights modern management strategies and the rationale for proton therapy in reducing long-term treatment toxicity in very young children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.