ArticleDusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi2026
Distinct fatigue profiles and psychological mechanisms among breast cancer survivors: A latent profile and mediation analysis.
Article in Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Cancer-related fatigue (CRF) is highly prevalent among breast cancer survivors. This study aimed to identify CRF subgroups in breast cancer survivors using latent profile analysis (LPA) and to examine the effects of rumination on CRF through anxiety, depression, and fear of cancer recurrence. Method: A total of 201 women diagnosed with early-stage breast cancer completed standardized assessments of fear of cancer recurrence, rumination, anxiety, depression, and cancer-related fatigue. Latent profile analysis was conducted to identify distinct CRF profiles, and differences in psychological variables across groups were examined. Mediation analyses were performed using the PROCESS macro with bootstrapping (5,000 samples) to test indirect effects. Results: LPA identified three distinct profiles: low (50.2%), moderate (37.3%), and high (12.4%). The model demonstrated excellent classification quality (entropy=0.80; average posterior probabilities=0.89-0.93). Participants in the high-CRF group reported significantly higher levels of rumination, anxiety, depression, and fear of recurrence than those in the other two groups (all p<0.001, η Conclusion: The findings suggest that fear of recurrence, anxiety, and depression may increase vulnerability to CRF. The results also underscore the importance of targeting transdiagnostic processes such as rumination in psychological interventions for breast cancer survivors.
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