Evidence map›Paper›PMID 42460086›Full record

ArticleFrontiers in medicine2026

Fluid-induced acid-base variations in postoperative critically ill patients: physiological determinants and renal response.

Francesco Zadek, Luca Zazzeron, Michele Ferrari, Davide Ottolina, Matteo Nafi, Floriana Ferrari, Eleonora Scotti, Federica Vagginelli, Marco Lattuada, Micah Liam Arthur Heldeweg and 4 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francesco Zadek *Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Luca Zazzeron *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.
Michele FerrariDepartment of Anesthesia and Intensive Care Medicine, Niguarda Ca' Granda, Milan, Italy.
Davide OttolinaUO Anestesia e Rianimazione, Ospedale di Saronno, ASST Valle Olona, Saronno, Italy.
Matteo NafiDepartment of Anesthesia and Intensive Care Medicine, IRCCS Multimedica, Sesto San Giovanni, Italy.
Floriana FerrariPediatric Intensive Care Unit, Department of Anesthesiology and Intensive Care, ASST Papa Giovanni XXIII, Bergamo, Italy.
Eleonora ScottiDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Federica VagginelliUO Anestesia e Rianimazione, Ospedale di Treviglio, ASST Bergamo Ovest, Treviglio, Italy.
Marco LattuadaAnaesthesia and Intensive Care Unit, E.O. Ospedali Galliera, Genoa, Italy.
Micah Liam Arthur HeldewegDepartment of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Lorenzo GiosaDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czechia.
Martin KrbecDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czechia.
Thomas LangerDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Pietro CaironiDepartment of Oncology, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alterations of acid-base balance induced by intravenous fluids are primarily related to changes in plasma strong ion difference (SID Methods: We conducted a prospective observational study in postoperative critically ill adults receiving intravenous fluids early after admission to intensive care unit (ICU). Fluid composition and volume were recorded. Acid-base variables, plasma and urinary electrolytes were assessed at ICU admission and study end (postoperative-day one). The average SID Results: Fifty-seven consecutive patients were included. Patients received 3,152 ± 1,027 mL of fluids, with a slightly positive fluid balance (+802 ± 1,212 mL) over 19 [18-20] hours. SID Conclusion: In postoperative critically ill patients, SID

Indexed as

acid–basebalanced solutionsbicarbonate concentrationcrystalloidsfluid therapyurine electrolyte excretion

Identifiers

PMID42460086
PMCPMC13369305

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